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Molecules isolated from venomous marine cone snails can be used to discover new drug leads for the treatment of chronic pain, depression and drug addiction. Cone snails use an elaborate biological harpoon mechanism to deliver deadly venom that swiftly immobilizes their fast moving prey. Their venom, which is composed of a complex mixture of disulfide rich peptides known as conotoxins, acts on an array on ion-channels and receptors in the central and peripheral nervous systems.