Torrey Pines Institute for Molecular Studies (TPIMS) is now occupying a newly-constructed, 100,000 square foot, state-of-the-art facility located in the Florida Center for Innovation in Port St. Lucie.

The work environment at TPIMS is one that fosters learning, training, development, and mentoring. The organization recognizes and values the diversity of its human capital and strives to provide a culture of mutual respect and an atmosphere that promotes collaboration, teamwork, and personal and professional growth.

TPIMS offers competitive salaries and a comprehensive benefits package.

TPIMS does not accept unsolicited resumes from individuals interested in future employment. Applicants must be applying for available posted positions and must follow the application procedures outlined.

TPIMS is an Equal Opportunity / Affirmative Action Employer

Positions Currently Available

• Scientific Grants Writer
• Senior Scientist
• Research Administrative Assistant
• Postdoctoral Research Fellow Positions
• Human Resources Manager
• Senior Faculty Positions

Torrey Pines Institute for Molecular Studies (TPIMS) is seeking a full-time Senior Scientist to manage the analytical chemistry group.  This position will primarily be responsible for managing/performing analytical and purification operations for the chemistry group.  The candidate will develop and implement novel techniques for analyzing mixture based libraries.

Additionally, TPIMS will be acquiring an ABS 3200 QTRAP and establishing on-site metabolite studies.  This position will take the lead in implementing the application of this instrument for those studies.  The candidate will also have the opportunity to take an active role in seeking out and contributing to grant and contract opportunities.

Candidates must possess a Ph.D. in a chemistry-related field with 1-3 years of experience in organic synthesis, lab management, and supervision of others; or the equivalent combination of education and experience.  Experience in HPLC purification and analytical techniques, especially LCMS/LCQ, is mandatory.  Experience with NMR, flash chromatography, normal phase, and SFC purification is preferred.  General laboratory and recordkeeping skills and a working knowledge of Microsoft Word and Excel for collection of data are required.  The successful candidate must be highly organized; able to maintain accurate and thorough lab notebooks; able to reason analytically; and be a team player who is committed, responsible, and able to lead and supervise others.

To apply for this position, application procedures must be strictly followed:

• Email resume to careers@tpims.org or mail to:  TPIMS, Attn HR, 3550 General Atomics Court, 2-129, San Diego, CA  92121
• Reference job # MG-012210 in the subject line of the email or on the envelope
• Use only one method to apply, email or mail

TPIMS is an Equal Opportunity / Affirmative Action Employer

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Torrey Pines Institute for Molecular Studies (TPIMS) is recruiting for a Research Administrative Assistant who will report to the Scientific Assistant to the President (SA).  He/she will be responsible for assisting the SA and Principal Investigators (PI's) with daily tasks, including the administrative preparation of grant proposals in accordance with the requirements of the granting agencies; maintaining journal databases; assisting SA and PI's with scientific manuscript drafts and submissions; updating SA and PI's biographical sketches; scheduling appointments;  composing and typing routine correspondence; filing; responding to telephone inquires; greeting visitors; arranging travel schedules, registrations, and reservations for scientific and other meetings; preparing expense documents for reimbursement; making copies; and preparing outgoing mail and overnight courier packages. 

The position will provide administrative and clerical assistance for scientific seminars hosted by the Institute, including the coordination of room scheduling and set-up, confirming one-on-one meetings between PI's and the guest speaker, arranging for presentation and equipment needs of the guest speaker.

Preferred candidates will possess a Bachelor's Degree and one to two years of related experience and/or training or the equivalent combination of education and experience.  Experience in a university or research setting is preferred.  Extreme attention to detail; high-level reading comprehension ability; strong command of English grammar; and the ability to function as a team-player are absolutely essential.

To apply for this position, application procedures must be strictly followed:

• Send your resume and cover letter by email to careers@tpims.org or mail to:
  TPIMS, Attn HR, 3550 General Atomics Court, 2-129, San Diego, CA  92121
• Reference job # KD-121309 in the subject line of the email or on the envelope
• Use only one method to apply, email or mail

TPIMS is an Equal Opportunity / Affirmative Action Employer

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Torrey Pines Institute for Molecular Studies (TPIMS) provides a unique and supportive environment, emphasizing diverse training opportunities in a state-of-the-art facility encompassing both academic and industrial experience.  Postdoctoral Research Fellows are trained and mentored directly by the Principal Investigator.  TPIMS offers a competitive benefits package, as well as the outstanding benefits of life on the Treasure Coast of Florida.

The following Postdoctoral Research Fellow positions are currently available.

TPIMS is an Equal Opportunity / Affirmative Action Employer

Postdoctoral Research Fellow

A Postdoctoral Research Fellow position is currently available in the laboratory of Colette Dooley, Ph.D., Assistant Member, to study the molecular mechanisms of opioid tolerance and dependence.  The candidate will be expected to conduct research examining the cellular mechanisms by which:

i) novel peptides induce GPCR internalization and
ii) screen mixture based combinatorial libraries in GPCR internalization assays to
iii) develop a receptor/ligand FRET assay. 

The applicant is expected to have 0-2 years of previous postdoctoral experience.  Experience in fluorescence microscopy is preferred and experience with radio-receptor binding assays and cell culture is advantageous. 

To apply for this position, please email your curriculum vitae and cover letter with contact information for three references to Dr. Colette Dooley at cdooley@tpims.org.

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Postdoctoral Research Fellow

A Postdoctoral Research Fellow position is currently available in the laboratory of Colette Dooley, Ph.D., Assistant Member, to study reactive oxygen species (ROS) as signaling agents between immune and nerve cells.  The candidate will be expected to conduct research examining the cellular mechanisms by which microglia cells produce ROS in response to opiates and the subsequent responses of nerve cells; develop orthogonal GFP-based fluorescent sensors; and perform live cell imaging.

The applicant is expected to have 0-2 years of previous postdoctoral experience.  Experience in fluorescence microscopy is required and experience with immune cell culture is advantageous. 

To apply for this position, please email your curriculum vitae and cover letter with contact information for three references to Dr. Colette Dooley at cdooley@tpims.org.

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Postdoctoral Research Fellow

A Postdoctoral Research Fellow position in medicinal chemistry is available in the laboratory of Chris Armishaw, Ph.D., Assistant Member. The successful applicant will apply combinatorial chemistry to structure-activity relationship studies of novel peptide analogs.  Specifically, the candidate will be required to:

i) design and synthesize combinatorial peptide libraries using solid phase chemistry;
ii) work with biologists to screen the combinatorial libraries for pharmacological activity; and
iii) use computational models to rationally design peptide analogs with refined pharmacological properties. 

The applicant should be a recent Ph.D graduate in an organic / medicinal chemistry related discipline, with less than 2 years of previous postdoctoral experience.  Ideally, the applicant will have working knowledge of analytical methods, including NMR, HPLC, and LC-MS.  Previous experience with solid-phase peptide chemistry is also preferred.  Successful candidates will be required to work within a dynamic and interdisciplinary team comprised of computational chemists, biochemists, and pharmacologists.

To apply for this position, please email your curriculum vitae and cover letter with contact information for three references to Dr. Chris Armishaw at carmishaw@tpims.org

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Postdoctoral Research Fellows

Two Postdoctoral Research Fellow positions are currently available in the laboratory of Jay McLaughlin, Ph.D., Associate Member.

The first position will examine G protein coupled receptor regulation and signaling in cellular and ex vivo mouse models.  A range of technical approaches will be used to determine the mechanisms underlying receptor mediation of novel ligand pharmacology derived from mixture-based combinatorial libraries.  Desirable applicants will possess a background in GPCR pharmacology and signal transduction. 

The second position will both screen novel compounds derived from mixture-based combinatorial libraries for analgesic and desirable pharmacological properties and determine the neuropharmacological mechanisms underlying behavioral effects using pharmacological and transgenic animal models.  Desirable applicants will possess experience with in vivo animal models.  Experience with immunohistochemical methods is also desirable, but not required. 

To apply, please email your curriculum vitae, the contact information for three references, and a cover letter describing your research interests to Dr. Jay P. McLaughlin at jmclaughlin@tpims.org.

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Postdoctoral Research Fellows

Two Postdoctoral Research Fellow positions are currently available in the laboratory of Madepalli Lakshmana, Ph.D., Associate Member. The long-term objective of our research is to discover molecular targets to reduce generation of amyloid beta peptide (Aβ) in mouse models of Alzheimer's disease. We recently demonstrated that RanBP9 increases Aβ generation in both cell cultures and APP transgenic mice. To further investigate the role of RanBP9 in Aβ production in vivo, we have successfully generated RanBP9 null mice using gene-trap strategy. Applicants with an interest in Alzheimer's disease are encouraged to apply.

Using both RanBP9 transgenic and knockout mice, the first postdoc will study the role of RanBP9 in dendritic and spine injury in a mouse model of Alzheimer's disease by crossing with APP transgenic mice. The successful candidate must have a background in neurobiology and extensive experience in immunohistochemical staining. Skills in basic molecular biology are a plus.

The second postdoc will identify RanBP9 binding proteins by yeast two-hybrid system and further explore their potential role in amyloidogenesis. Desirable applicants must possess strong molecular biological skills in addition to knowledge in neurobiology.

To apply, please email your curriculum vitae, the contact information for three scientific references, and a cover letter describing your research interests to Dr. Madepalli Lakshmana at mlakshmana@tpims.org.

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Torrey Pines Institute for Molecular Studies (TPIMS) is recruiting for a full-time Human Resources Manager at its Port St. Lucie, Florida site who will report to the Vice President of Administration and be responsible for the day-to-day hands-on human resources functions at the Port St. Lucie, Florida site, including but not limited to recruiting, employee relations, benefits and compensation administration, safety, recordkeeping, payroll, performance management, training, and employee leaves of absence.

Essential job duties and responsibilities for this position include:

• Manages and conducts all recruiting activities and trains hiring managers in understanding proper recruiting, interviewing, hiring, and training for compliance with EEO and Affirmative Action requirements and goals.
• Works closely with employees and supervisors to ensure consistent and fair resolution of employee relations issues and recommends solutions.
• Communicates policies, procedures, and practices of the organization to employees and ensures consistent compliance.
• Ensures consistent application of performance management and performance improvement practices.
• Administers the performance management system and provides ongoing support and coaching to employees and supervisors.
• Conducts benefit open enrollment meetings annually and provides ongoing benefit administration.
• Enrolls new employees in all benefit-related programs and assists employees with benefit questions and issues.
• Reconciles and processes benefit invoices and ensures timely payments are sent to benefit carriers.  Resolves invoice discrepancies with the benefit carriers and ensures any necessary adjustments are made.
• Conducts employee termination meetings, ensuring all required paperwork is provided to employee, final pay calculated and provided, and all organization property returned from employee.
• Ensures compensation decisions are in accordance with organization policies and provides compensation data and coaching to managers.
• Coordinates with the safety officer in administering a general safety program and communicates safety-related issues to employees.
• Provides general training for employees in relation to safety or other necessary areas.
• Ensures compliance with state and federal employment laws.
• Coordinates with the CA office on payroll processing and recordkeeping.
• Performs new hire orientations and coordinates a smooth on-boarding transition.
• Maintains employee personnel records, including paper and electronic files.
• Reports workplace injuries, provides employee assistance for medical care, and ensures compliance with OSHA reporting regulations.
• Administers employee leaves of absence and ensures proper documentation and tracking for FMLA, workers compensation, military leave, short-term and long-term disability, personal leaves and any other statutory or organization-granted leaves.
• Provides supervisory oversight to the front desk receptionist and any additional administrative or HR support personnel positions, as may be feasible and relevant.
• Other duties as assigned.

Qualifications:

• Bachelor's Degree from an accredited university in Human Resources or related field preferred or the equivalent combination of education and experience.
• PHR or SPHR certification preferred.
• Professional Certificate in Human Resources from an accredited university preferred.
• At least five years of human resources generalist experience.
• Must be computer literate with advanced proficiency in Microsoft Outlook, Word, and Excel.
• Prior experience with an HRIS system is a plus.
• Prior experience in a research or biotech environment a plus.
• Extensive knowledge of Florida and federal employment law.
• Able to build positive working relationships with a variety of different personalities.
• Must be a hands-on manager who is able to work independently, multi-task, and balance multiple priorities.
• Able to see a broad perspective on issues and consider alternatives.
• Must be able to work calmly under pressure and think strategically and possess strong analytical and problem solving skills.
• Attention to detail is critical.
• Able to maintain a high level of confidentiality and professionalism is imperative.
• Proven ability to utilize good judgment and make sound decisions.
• Basic math skills, including the ability to add, subtract, multiply, divide, and calculate percentages required.
• Excellent organizational, prioritization, time management, and customer service skills are essential.
• Must be a team player with excellent interpersonal, verbal and written communication skills.
• Previous supervisory experience preferred.
• Knowledge of OSHA reporting requirements, administration of general safety procedures, and workers compensation/workplace injury reporting and administration.
• Dependability, commitment, and a sense of ownership in the organization is a must.

To apply for this position, please follow the application procedures outlined below:

• Send resume and cover letter outlining relevance of qualifications for this position (Microsoft Word or Adobe Acrobat format) by email to careers@tpims.org or mail to TPIMS, Attn HR, 3550 Atomics Court, 2-129, San Diego, CA 92121
• Reference job # KG-020310 in the subject line of the email or on the envelope
• Use only one method to apply, email or mail
  
  TPIMS is an Equal Opportunity / Affirmative Action Employer

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TPIMS is currently seeking Senior Faculty Members for our location in Port St. Lucie, Florida.  Successful candidates must have a Ph.D., M.D., or equivalent degree and an established record of independent research accomplishment, including existing extramural funding.  Investigators with active R01 awards or equivalent funding are encouraged to apply.  All research areas will be considered, but preference will be given to synthetic organic medicinal chemists and disease-oriented animal model biologists, particularly in the areas of pharmacology and neuropharmacology.  Those selected will be expected to further develop, manage, and maintain their own independent, extramurally funded research program(s).

Outstanding incentives and start-up packages are available, commensurate with experience and program strength.

To apply, please send a Curriculum Vitae with a full list of publications, statement of research interests and plans, funding history, and names of three references to: facultycareers@tpims.org or by fax, to the human resources office at 858.597.3837.

TPIMS is an Equal Opportunity / Affirmative Action Employer

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TPIMS has an approved Exchange Visitor program in place which allows research scholars from other countries to come to the United States on a J-1 Visa sponsored by TPIMS. Scholars may conduct research at TPIMS for a period of three months to three years. Successful candidates will have a recent Ph.D. in or relating to the disciplines of Chemistry, Biochemistry, Immunology, Molecular Biology, or Microbiology.