Obesity & Diabetes Research
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Dr. Samad’s research focuses on the contribution of adipose tissue to the pathogenesis of obesity and related health consequences including: insulin resistance, type 2 diabetes, fatty liver and increased risk for cardiovascular disease and cancer. She was a pioneer in demonstrating an endocrine role for adipose tissue by demonstrating that a number of pro-thrombotic and inflammatory proteins are expressed in adipocytes/adipose tissues and elevated in obesity. She has worked and published extensively on pro thrombotic (plasminogen activator inhibito-1, tissue factor), inflammatory mediators, and related signaling pathways up regulated in the obese adipose tissue that may contribute to the pathogenesis of the metabolic syndrome. Her most recent research suggests that sphingolipids, including ceramide, sphingosine, and sphingosine 1 phosphate, are potential lipid signaling molecules that may link elevated levels of free fatty acids and inflammation due to obesity to insulin resistance/type 2 diabetes and cardiovascular risk.
Fahumiya Samad, Ph.D is an Associate Member at Torrey Pines Institute for Molecular Studies. Dr. Samad received her Ph.D in Biology (Immunology) from The University of Wisconsin, and completed post-doctoral training at The Scripps Research Institute in the laboratory of Dr. David J Loskutoff after which she joined the Department of Vascular Biology at Scripps as an Assistant Professor. Prior to moving to the Torrey Pines Institute for Molecular Studies, from 2004-2006, she was an Associate Professor at the La Jolla Institute for Molecular Studies.
She is also “Editor-In-Chief” of Adipocyte, the first international peer-reviewed journal for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology.
- Ph.D., Biology, University of Wisconsin-Milwaukee, WI, 1990
- M.S., Biology, University of Maine- Orono, ME, 1984
- B.S., Biology, University of Colombo-Sri Lanka, 1980, first class honors
- Aug 2006-present - Associate Member, Torrey Pines Institute for Molecular Studies, San Diego, CA
- July 2004 - July 2006 - Associate Professor, La Jolla Institute for Molecular Medicine, San Diego, CA
- Jan 1999 - July 2004 - Assistant Professor, Dept. of Cell Biology, division of Vascular Biology, The Scripps Research Institute, La Jolla, CA
- Nov 1996 - Jan 1999 - Senior Research Associate, The Scripps Research Institute, La Jolla, CA
- Nov 1992 - Nov 1996 - Research Associate, The Scripps Research Institute, La Jolla, CA
- Nov 1989 - Nov 1992 - Postdoctoral Fellow, Dept. of Health and Biological Sciences, University of Wisconsin, Milwaukee, Wisconsin
- Sept 1989 - May 1990 - Associate Lecturer, Dept. of Biological Sciences, University of Wisconsin, Milwaukee, Wisconsin
- Sept 1984 - Sept 1989 - Teaching Assistant/Research Assistant, Dept. of Biological Sciences, University of Wisconsin, Milwaukee, Wisconsin
- Sept 1982 - Aug 1984 - Research Assistant, Cooperative Fisheries Research Unit, University of Maine, Orono, Maine
- Sept 1980 - Aug 1982 Assistant Lecturer/Research Assistant, Dept. of Biology, University of Colombo, Sri Lanka
- American Diabetes Association
- American Heart Association (Council Member: Arteriosclerosis Thrombosis and Vascular Biology)
- International Society for Thrombosis and Hemostasis
- International Society for Fibrinolysis and Proteolysis
- American Association for the Advancement of Science
Honors and Awards
- Fulbright Fellow, USIA and the Institute of International Education, Washington, D.C., 1982.
- University of Maine-Orono. Cooperative Fisheries Research Unit. Tuition Scholarship, 1982.
- University of Wisconsin-Milwaukee. Non-resident tuition scholarship, 1984.
- American Heart Association, California Affiliate, Postdoctoral Fellowship Award, 1994.
Selected Publications (10 of 36)
- Samad, F., Yamamoto, K. and Loskutoff, D.J. (1996). Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo: Induction by tumor necrosis factor-a and lipopolysaccharide. J. Clin. Invest. 97:37-46. PMID: 8550848
- Samad, F., Pandey, M. and Loskutoff, D.J. (1998). Tissue factor gene expression in the adipose tissues of obese mice. Proc. Natl. Acad. Sci. USA. 95:7591-7599. PMID: 9636194
- Samad, F., Hotamisligil, G.S., Uysal, K.T., Pandey, M., Weisbrock, S.M. and Loskutoff, D.J. (1999). Tumor Necrosis Factor-a: A key component in the obesity-linked elevation of plasminogen activator inhibitor-1. Proc. Natl. Acad. Sci. USA 96:6902-6907. PMID: 10359811
- Pandey, M., Uysal, K.T., Tuncman, G., Hotamisligil, G.S., and Samad, F. (2003). Divergent roles for p55 and p75 TNF-a receptors in the induction of plasminogen activator inhibitor-1. Am.J.Pathol. 162:933-941. PMID: 12598326
- Jaap G. Neels, Manjula Pandey, Gökhan S. Hotamisligil, and Fahumiya Samad (2006). Auto-amplification of TNF-α: A potential mechanism for the maintenance of elevated TNF-α in male but not female obese mice. Am. J. Pathol. 168:435-444. PMID: 16436658
- Samad F, Hester KD, Yang G, Hannun, YA, Bielawski, J. (2006) Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes, 55:2579-2587. PMID: 16936207
- Shah C, Yang G, Lee I, Bielawski J, Hannun YA, and Samad F. (2008) Protection from high fat diet induced increase in ceramide in mice packing plasminogen activator inhibitor 1. J. Biol. Chem. 283:13538-13548. PMID: 18359942
- Neels GN, Badeanlou L, Hester KD, and Samad F. (2009) Keratinocyte-derived Chemokine in Obesity: Expression and Role in Adipose Macrophage Infiltration and Glucose homeostasis. J Biol Chem. 2009 Jul 31;284(31):20692-8. Epub 2009 Jun 3. PMID: 19494115.
- Yang G, Badeanlou L, Bielawski J, Hannun YA, and Samad F (2009) Central role for ceramide biosynthesis in body weight regulation, energy metabolism and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E211-24. Epub 2009 May 12. PMID: 19435851 .
- Badeanlou, L., Furlan-Freguia, C., Yang, G., Ruf, W., Samad, F. (2011). Tissue factor-protease activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation. Nature Medicine. 17:1490-1497. (News and Views: Nature Medicine 17, 1343-1344, 2011).