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Meet Our California Scientists Ingrid Schraufstatter
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Ingrid Schraufstatter

Ingrid SchraufstatterTorreyPinesInstituteCA

Associate Member
Immunology

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858.909.5141 - fax
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Dr. Schraufstatter has a long-standing interest in the factors and mechanisms that cause cell migration. These factors include chemokines and the complement split products C3a and C5a, which are small-sized proteins or protein split products produced during any inflammatory process. Previously her research focused on how white blood cells are chemo-attracted by these factors in inflammation. However, it has become evident over the past decade that cancer cells and various stem cells respond to the same chemotactic stimuli: In the case of cancer cells this can result in metastasis, in the case of stem cells it allows recruitment of these cells to a site of tissue injury followed by tissue repair. Recent work in Dr. Schraufstatter’s laboratory shows that C3a and C5a are potent chemotactic factors for mesenchymal stem cells, which induce the production of various trophic factors by these cells. Current interests include determining the role of C3a and C5a in the stimulation and recruitment of adult stem cells (mesenchymal and neural stem cells), the discovery of additional chemotactic factors for these cells and definition of the signaling cascades that they activate. While these efforts are primarily directed at a better understanding of basic stem cell biology, such understanding may eventually lead to improved means of cell delivery during stem cell transplantation as well as to the identification of means to augment endogenous stem cell recruitment following tissue damage.

Dr. Schraufstatter earned her M.D. from the University of Aachen in Germany in 1980 and completed her studies in pharmacology at King's College in London, UK and in immunology at the Scripps Research Institute in La Jolla, CA. She was an Assistant Professor at The Scripps Research Institute in La Jolla, CA from 1989 - 1999 in the Department of Immunology. From 1999 - 2007 she was a faculty member at the La Jolla Institute for Molecular Medicine in San Diego, CA. Dr. Schraufstatter joined  Torrey Pines Institute for Molecular Studies in 2007, and since 2010 she is an Associate Member in the Immunology and Cell Biology Departments at TPIMS. Dr. Schraufstatter has 72 publications.

Education

  • 1980, M.D., University of Aachen, Germany

Academic Positions

  • 2010-       :  Associate Member, TPIMS, San Diego, CA
  • 2007-2010: Adjunct Member, TPIMS, San Diego, CA
  • 1999-2007: Member, La Jolla Institute for Molecular Medicine, San Diego, CA
  • 1989-1999: Assistant Member, The Scripps Research Institute, La Jolla, CA, Department of Immunology
  • 1981-1989: Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA, Department of Immunology
  • 1980-1981: Postdoctoral Fellow, King’s College, London, UK, Department of Pharmacology

Professional Affiliations

  • 1989-         : Member, American Association of Immunologists

Honors & Awards

  • 1980-1981    : Fellowship, Deutsche Forschungsgemeinschaft (DFG)
  • 1983-1986    : Parker B. Francis Fellow in Pulmonary Research
  • 1989-present        : Recipient of grants from NIH (RO1, R21), The Congressionally Directed Medical Research Program, California Breast Cancer Program and the California Tobacco Research Program
  • 1992-4, 2005, 2006, 2010: Ad hoc reviewer for NIH
  • 2006-2009: Peer Review Member, Western Review Consortium, American Heart Association
  • 2009 - present: Programmatic Reviewer for the Congressionally Directed Medical Research Program in Breast Cancer
  • 2007- present         : Associate Editor: American Journal of Physiology Lung Cell Molecular Physiology
  • Ad hoc reviewer for: Journal of Immunology, Blood, Journal of Biological Chemistry, Journal of Clinical Investigation, Cancer Research, Stem Cells and others

Selected Publications (10 of 75)

  1. Schraufstatter I., DiScipio R.G., Zhao M., and Khaldoyanidi S.K., C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation, J. Immunol., 2009, 182 : 3827-3836
  2. Wimmer A., Khaldoyanidi S.K., Judex M., Serobyan N., Discipio R.G., Schraufstatter I.U. CCL18/PARC stimulates hematopoiesis in long-term bone-marrow cultures indirectly through its effect on monocytes, Blood. 2006, 108 : 3722-3729
  3. Zhao M., DiScipio R., Wimmer A., and Schraufstatter I., Regulation of CXCR4-mediated nuclear translocation of ERK1/2, Mol. Pharmacol., 2006, 69 : 66-75
  4. Burger M., Hartmann T., Burger J.A., and Schraufstatter I., KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway, Oncogene, 2005, 24 : 2067-2075
  5. Zhao M., Wimmer A., Trieu K., DiScipio R.G., and Schraufstatter I.U., Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2, J. Biol. Chem., 2004, 279 : 49259-49267
  6. Schraufstatter I.U., Trieu K., Rose D., Terkeltaub R.A., and Burger M., IL-8 mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the EGF-receptor, J. Immunol., 2003, 171 : 6714-6722
  7. Schraufstatter I.U., Trieu K., Sikora L., Sriramarao P., and DiScipio R.D., Complement C3a and C5a induce different signal transduction cascades in endothelial cells, J. Immunol. 169 : 2102-2110, 2002
  8. Burger M., Burger J.A., Hoch R.C., Oades Z., Takamori H., and Schraufstatter I.U., Point mutation causing constitutive signaling of the CXCR2 leads to transforming activity similar to KSRV-GPCR, J. Immunol., 1999, 163 : 2017-2022
  9. Schraufstatter I.U., Barritt D.S., Ma M., Oades Z., and Cochrane C.G., Multiple sites on IL-8 responsible for binding to alpha and beta-IL-8 receptors. J. Immunol. 1993, 151 : 6418-6428
  10. Schraufstatter I.U., Hyslop P.A., Hinshaw D.B., Spragg R.G., Sklar L.A., and Cochrane C.G., Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase., Proc. Natl. Acad. Sci. U S A. 1986, 83 : 4908-4912

Patents

Schraufstatter I.U., and Cochrane C.G., Interleukin-8 anti-peptide antibodies (# 5,831,032), issued Nov. 1998