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Meet Our Florida Scientists Dmitriy Minond
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Dmitriy Minond

Dmitriy_Minond TorreyPinesInstituteFL

Assistant Member
Cancer Research,
Lead Discovery
spacer_scientists

772.345.4705 - phone
772.345.3649 - fax
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Dr. Minond studies the role of ADAM family metalloproteases in cancer progression. His program includes discovering and/or developing small molecule selective probes/leads and utilization of these molecules in cell based studies in order to discover potential drug candidates.

Dr. Minond completed his undergraduate studies in Biology and Biochemistry in 1993 from the Odessa State University of Odessa, Ukraine, and his Ph.D. in Chemistry and Biochemistry at the Florida Atlantic University, Boca Raton, Florida ("The Roles of Substrate Sequence and Thermal Stability in the Collagenolytic Action of Matrix Metalloproteinases ") in 2006. He then joined the Translational Research Institute of The Scripps Research Institute as a post doctoral associate under Professor Peter S. Hodder. In 2009 he was promoted to a Senior Scientist position. Dr. Minond has 12 publications. Dr. Minond joined the Torrey Pines Institute in August 2010 as an Assistant Member.

Education

Ph.D. in Chemistry and Biochemistry.  Florida Atlantic University, Boca Raton, Florida.

Master of Science degree in Biology and Biochemistry. Odessa State University, Odessa, Ukraine


Positions

2010-Present  Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida.  Assistant Member/Primary Investigator.

2009-2010  Translational Research Institute, Scripps Florida, Jupiter, Florida. Senior Scientist - HTS Lead ID Department.

2006-2008  Translational Research Institute, Scripps Florida, Jupiter, Florida. Scientific Associate – HTS Lead ID Department.

2002-2006  Chemistry and Biochemistry Department, Florida Atlantic University - Boca Raton, Florida.  Ph.D. Student.

2001-2002  Noven Pharmaceuticals, Inc., Miami, Florida.  Analytical R&D - Analytical Chemist.

1995-2001  US Biosystems, Boca Raton, Florida.  Analytical Chemist.

Honors & Awards

  • 2007-2008    AAAS/Science Program for Excellence in Science Fellowship
  • 2006            FAU Student Council Award for Research Excellence

 

Selected Publications (10 of 12)

  1. Weide T*, Saldanha SA*, Minond D*, Spicer TP, Fotsing JR, Spaargaren M, Frère JM, Bebrone C, Sharpless KB, Hodder PS, Fokin VV. NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-beta-Lactamase: Synthesis and Structure-Activity Studies. ACS Med Chem Lett. 2010 Jul 8;1(4):150-154.
  2. Minond D, Saldanha SA, Subramaniam P, Spaargaren M, Spicer T, Fotsing JR, Weide T, Fokin VV, Sharpless KB, Galleni M, Bebrone C, Lassaux P, Hodder P. Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries Bioorg Med Chem. 2009 Jul 15;17(14):5027-37.
  3. Janelle L. Lauer-Fields, Michael J. Chalmers, Scott A. Busby, Robert Visse, Dmitriy Minond, Hideaki Nagase, Patrick R. Griffin, and Gregg B. Fields. Identification of Specific Hemopexin-like Domain Residues That Facilitate Matrix Metalloproteinase Collagenolytic Activity J Biol Chem. 2009 Sep 4;284(36):24017-24
  4. Lauer-Fields JL, Minond D, Chase PS, Baillargeon PE, Saldanha SA, Stawikowska R, Hodder P, Fields GB. High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate. Bioorg Med Chem. 2009 Feb 1;17(3):990-1005.
  5. Schröter T*, Minond D*, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, Hodder P. Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II). J Biomol Screen. 2008 Jan;13(1):17-28.
  6. Lauer-Fields JL, Minond D, Brew K, Fields GB.Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors. Methods Mol Biol. 2007; 386:125-66.
  7. Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Moss ML, Fields GB. Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences. Biochemistry. 2007 Mar 27; 46(12): 3724-33.
  8. Lauer-Fields JL, Minond D, Sritharan T, Kashiwagi M, Nagase H, Fields GB. Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases. J Biol Chem. 2007 Jan 5;282(1):142-50.
  9. Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Visse R, Nagase H, Fields GB. The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity. J Biol Chem. 2006 Dec 15; 281(50): 38302-13.
  10. Minond D, Lauer-Fields JL, Nagase H, Fields GB. Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability. Biochemistry. 2004 Sep 14; 43(36):11474-81.