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Mr. Giulianotti’s research focuses on identifying potential human therapeutics and diagnostics as well as agricultural treatments. The research group combines novel approaches in combinatorial chemistry, computer-aided drug design and mathematics. The research group is currently involved in a number of different interdisciplinary projects with internal and external collaborators focusing in areas such as pain management, cancer, obesity, stroke and citrus greening.
Marc Giulianotti earned his Bachelor of Science in Chemistry and Biochemistry from the University of California, San Diego in 1995 and his Masters in Business Administration from San Diego State University in 2001. Marc joined the Torrey Pines Institute as a Research Associate in 1995 and his research focused on design of novel combinatorial libraries. He held this position until 2001 and then became the Business Development Manager for Mixture Sciences, Inc., a Torrey Pines spin-off company. Marc was tapped as Director of Chemistry Operations for the Torrey Pines Institute's Florida base in June 2007.
- 2001 – Master of Business Administration (Information Technology), San Diego State University, San Diego, CA
- 1995 - Bachelor of Science (Chemistry/Bio-chemistry), University of California, San Diego, San Diego, CA
- 2007 - Present: Director of Chemistry Operations, Torrey Pines Institute for Molecular Studies, Port St Lucie, Florida
- 2001 - 2007: Business Development Manager, Mixture Sciences, Inc., San Diego, California
- 1995 - 2001: Research Associate, Torrey Pines Institute for Molecular Studies, San Diego, California
Selected Publications (10 of 35)
- Giulianotti, M., Nefzi, A. Efficient approach for the diversity-oriented synthesis of macro-heterocycles on solid-support. 2003 Tetrahedron Letters 44: 5307-5309.
- Sospedra, M., Muraro, P., Stefanova, I., Zhao, Y., Chung, K., Li, Y., Giulianotti, M., Simon, R., Mariuzza, R., Pinilla, C., Martin, R. Redundancy in Antigen-Presenting Function of the HLA-DR and -DQ Molecules in the Multiple Sclerosis-AssociatedHLA-DR2 Haplotype. 2006 J. Immunol. 36:1951-1961.
- Medina-Franco, J.L., Maggiora, G.M., Giulianotti, M., Pinilla, C., Houghen, R.A. A Similarity-based Data-fusion Approach to the Visual Characterization and Comparison of Compound Databases. Chem. Biol. Drug Des. 70(5):393-412, 2007.
- Houghten, R.A., Pinilla, C., Giulianotti, M.A., Appel, J.R., Dooley, C.T., Nefzi, A., Ostresh, J.M., Yu, Y., Maggiora, G.M., Medina-Franco, J.L., Brunner, D. and Schneider, J. Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvultion by computational methods. J. of Comb.Chem. 10 (1):3-19, 2007.
- Medina-Franco, J.L., Martínez-Mayorga, K., Giulianotti, M.A., Houghten, R.A., Pinilla, C. Visualization of the Chemical Space in Drug Discovery. Curr.Comput.Aided Drug Des. 4:323-334, 2008.
- Martinez-Mayorga, K., Medina-Franco, J., Giulianotti, M.A., Pinilla, C., Dooley, C.T., Appel, J.R. and Houghten, R.A. Conformation-Opioid Activity Relationships of Bicyclic Guanidines from 3D Similarity Analysis. Bioorg. Med. Chem. 16(11):5932-5938, 2008. Epub Apr 27, 2008.
- Li Y, Yu Y, Giulianotti M, Houghten RA. One-Pot High-Throughput Synthesis of beta-Turn Cyclic Peptidomimetics via "Volatilizable" Supports. J Org Chem. 2009 Jan 27.
- Medina-Franco JL, Martínez-Mayorga K, Bender A, Marín RM, Giulianotti MA, Pinilla C, Houghten RA. Characterization of Activity Landscapes Using 2D and 3D Similarity Methods: Consensus Activity Cliffs. J Chem Inf Model. 2009 Jan 30.
- Sospedra, M., Zhao, Y., Giulianotti, M., Simon, R., Pinilla, C., Martin, R. Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones 2010 Journal of Immunological Methods 353: 93–101.
- Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library. AAPS J. 2010 Apr 27.