Insulin Resistance/Type 2 Diabetes, Cardiovascular Disease

Given the disease burden and health costs associated with the increased prevalence of obesity, identifying mechanisms in the pathogenesis of obesity and associated health disorders is crucial for the development of rational therapeutic options. The major interest in the Samad laboratory is to study the extra cellular mediators and intracellular molecular mechanisms involved in the pathogenesis of obesity and related health consequences including increased risk for insulin resistance/type 2 diabetes and cardiovascular disease.

Learn More >> Obesity and Increased Risk for Breast Cancer

Clinical studies suggest and obesity increases the risk for breast cancer and there is convincing evidence that post-menopausal breast cancer risk is highly correlated with serum estrogen levels. One potential link between obesity and breast cancer risk is increased estrogen production by the adipose tissue itself.

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