University Degrees

1992 – Ph.D. Immunology
Pierre & Marie Curie University, Paris 6, France.

1981-M.S.Master in Oceanography
Lumigny University, Marseille, France.

1979 -Pharmaceutical Doctorate (Pharm.D.)
Timone University, Marseille, France

Titles and Functions

June 2006-present
Associate Member, Torrey Pines Institute for Molecular Studies

2003-2006
Senior Research Scientist. Pr. Jan Schnitzer's laboratory.
Vascular Biology Department. Sidney Kimmel Cancer Center, San Diego

2002-2003
Senior Research Associate . Pr. Joel Gottesfeld's laboratory
Molecular Biology Department. The Scripps Research Institute, San Diego

1999-2002
Senior Research Scientist. Pr. Per Borgstrom's laboratory.
Vascular Biology Department Sidney Kimmel Cancer Center, San Diego

1994 – 1999
Staff Scientist (level Assistant Professor) Pasteur Institute. Paris working as:

• Visiting Scientist Pr. Dan Gold's laboratory (1998-1999) Sidney Kimmel Cancer Center. San Diego
• Visiting Scientist at UCSD Cancer Center. Pr Malcolm Mitchel's laboratory. (1997-1998)
• Visiting Scientist at the R.W. Johnson Pharmaceutical Research Institute. Pr. Per Peterson's laboratory San Diego. (1994-1997)

1992 – 1994
Staff Scientist ( level Assistant Professor), Pasteur Institute, Paris.
Pr. Daniel Louvard's laboratory, Cellular Biology Department.

1985 – 1992
Staff Scientist, Pasteur Institute,Paris.
Pr. Daniel Louvard's laboratory, Cellular Biology Department.

1981 – 1985
Assistant Professor, Clinical Biochemistry Department
St Antoine Medical School (Paris 6 University) and Rothschild Hospital
Paris, France

1979 – 1080
Staff Scientist : Prof. Ranque's laboratory. Department of Clinical
Biochemistry. Houphouet Boigny Hospital. Marseille France.

1976 – 1980
Resident (Clinical Biochemistry) Marseille, France

• 1977 – 1979 Pr. Arnoux's laboratory. Marseille Cancer Center
• 1976 – 1977 Pr. Pastor's laboratory, St Marguerite Hospital. Marseille France

Teaching Responsibilities

Between 1981 and 1985, as Assistant Professor, Course of Clinical Biochemistry
Medical School of St AntoineUniversity - Paris 6.

Awards

Fellowship award from the C.N.R.S. ( National Center for Scientific Research)
Paris. France.”Isolation and determination of molecular structure of Saponins and Sapogenins from Actinopygaflammea, a marine invertebrate of the New Caledonian Lagoon.”

Grants

2004-2007
Awarded as principal investigator from the Department of Defense Prostate Cancer Research Program (New Idea Award. Reference: PC040264 )- “Vascular Targeting of Spontaneous Prostate Cancer with Dendritic Cell-Based Vaccine”.

1991 and 1992
Awarded from the “Ligue pour la Recherche sur le Cancer” (League for Cancer Research)-“Interet de la villine en temps que marqueur tumoral des cancers colorectaux. (Use of Villin as tumoral marker for colorectal cancer) “

Publications

1. Frost, G.I., Lustgarten, J., Dudouet, B., Nyberg, L., Hartley-Asp, B., Borgstrom, P. Novel syngeneic pseudo-orthotopic prostate cancer model: vascular, mitotic and apoptotic responses to castration. Microvasc. Res. 69:1-9, 2005.

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2. Dudouet, B., Burnett, R., Dickinson, L.A., Wood, M.R., Melander, C., Belitsky, J.M., Edelson, B., Wurtz, N., Briehn, C., Dervan, P.B., Gottesfeld, J.M. Accessibility of nuclear chromatin by DNA binding polyamides. Chem. Biol. 10:859-867, 2003.
3. Frost, G.I., Dudouet, B., Lustgarten, J., Borgstrom, P. The roles of epithelial-mesenchymal interactions and the innate immune response on the tumorigenicity of human prostate carcinoma cell lines grown in immuno-compromised mice. In Vivo 17:377-388, 2003.

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4. Minev, B.R., Chavez, F.L., Dudouet, B.M., Mitchell, M.S. Synthetic insertion signal sequences enhance MHC class I presentation of a peptide from the melanoma antigen MART-1. Eur. J. Immunol. 30:2115-2124, 2000.

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5. Dudouet, B., Aznard, C., Boisson, M., Mousson, L., Mazie, J.C., Louvard, D., Garrigue, G. Villin an enterocyte cytoskeletal protein, in diagnosis and follow up of colorectal cancers. Comparison with carcinoembryonic antigen. Acta Endoscopica No. 1, Volume 21, 1991.
6. Louvard, D., Arpin, M., Coudrier, E., Dudouet, B., Finidori, J., Garcia, A., Godefroy, O., Pringault, E., Robine S., Sahuquillo-Merino, C. Differentiation of a multipotent human intestinal cell line: Expression of villin, a structural component of brush-borders. Molecular mechanisms. Cellular growth and differentiation. Eds., Bellve, A.R., Vogel, H.J., Academic Press, Inc. pp. 341-353, 1991.

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7. Dudouet, B., Jacob, L., Beuzeboc, P., Magdelenat, H., Robine, S., Chapuis, Y., Christoforov, B., Cremer, G.A., Pouillard, P., Bonnichon, P., Pointereau, A., Bellanger, J., Maunoury, M., Louvard, D. Presence of villin, a tissue-specific cytoskeletal protein, in sera of patients and an initial clinical evaluation of its value for the diagnosis and follow-up of colorectal cancers Cancer Res. 50:438-443, 1990.

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8. Arpin, M., Coudrier, E., Dudouet, B., Finidori, J., Garcia, A., Huet, C., Pringault, E., Robine, S., Sahuquillo-Merino, C., Louvard, D. The actin binding protein, villin: an early differentiation marker of intestinal epithelial cells. Hormones and cell regulation. No. 13., Ed., Nunez, J., Colloque INSERM/John Libbey Eurotext Ltd. Vol. 17, pp. 53-63, 1989.
9. Louvard, D., Arpin, M., Coudrier, E., Dudouet, B., Finidori, J., Garcia, A., Huet, C., Pringault, E., Robine, S., Sahuquillo-Merino, C. Use of villin for the histopathological and serological diagnosis of digestive cancers. Cytoskeletal proteins in tumor diagnosis. Current Communications in Molecular Biology, (CSH), pp. 201-213, 1989.

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10. Arpin, M., Blair, L., Coudrier, E., Dudouet, B., Finidori, J., Garcia, A., Huet, C., Pringault, E., Robine, S., Sahuguillo-Merino, C., Louvard, D. Villin, a specific marker for some epithelia specialized in transport, to study the differentiation of intestinal and kidney cells in vivo and in a human colon adenocarcinoma line HT29 in culture. Mol. Aspects Med. 10:257-272, 1988.
11. Coudrier, E., Arpin, M., Dudouet, B., Finidori, J., Garcia, A., Huet, C., Pringault, E., Robine, S., Sahuquillo-Merino, C., Louvard, D. Villin, a structural marker to study the assembly of the brush border. Protoplasma 145:99-105, 1988.

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12. Dudouet, B., Robine, S., Huet, C., Sahuquillo-Merino, C., Blair, L., Coudrier, E., Louvard, D. Changes in villin synthesis and subcellular distribution during intestinal differentiation of HT29-18 clones. J. Cell Biol. 105:359-369, 1987.
13. Dudouet, B., Robine, S., Louvard, D. Intérêt de la villine, un marqueur de la différenciation des épithéliums digestifs, en anatomopathologie et en biologie clinique. Encyclopédie Médico-Chirurgicale 4:19-22, 1987.
14. Figiel, A., Schilt, J., Dudouet, B., Robine, S., Dauca, M. Stage-specific polypeptides and villin expression during the intestinal epithelium substitution of the metamorphosing amphibian. Differentiation 36:116-124, 1987.
15. Moll, R., Robine, S., Dudouet, B., Louvard, D. Villin: a cytoskeletal protein and a differentiation marker expressed in some human adenocarcinomas. Virchows Arch B Cell Pathol. Incl. Mol. Pathol. 54:155-169, 1987.
16. Robine, S., Dudouet, B., Louvard, D. La villine: marqueur de différenciation. Applications en pathologie. Médecine et Sciences, Ed. Libbey, J., Eurotext Ltd, 3:479-48, 1987.

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17. Louvard, D., Arpin, M., Blair, L., Coudrier, F., Dudouet, B., Finidori, J., Garcia, A., Godefroy, O., Huet, C., Pringault, E., Robine, S., Sahuquillo-Morino, C. Differentiation of a human adenocrcinoma (HT29) in culture :a model to study assembly of membrane specialisation and cell surface polarity in eptihelia. Proc. XIth. Int. Cong. on Electron Microscopy, Kyoto, 1851-1853, 1986.

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18. Bhatnagar, S., Dudouet, B., Ahond, A., Poupa, C., Thoison, O., Clastre, A., Laurent, D., Potier, P. Marine invertebrates of the new caledonian lagoon: saponins and sapogenins from the sea cucumber, Actinopygaflammea. Bull. Soc. Chim. Fr. 1:124-129, 1985.

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Patents

1. Antibodies which recognize and bind human villin. U.S. Patent No. 5,635,389. Issued June 3, 1997.   Inventors:  Louvard, D., Dudouet, B., Robine, S., Arpin, M., Pringault, E., Garcia, A.

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2. Agents for the in vitro diagnosis of malignant cells originating in the digestive tract. U.S. Patent No. 5,188,967. Issued February 23, 1993.   Inventors:  Louvard, D., Dudouet, B., Arpin, M., Pringault, E., Garcia, A.