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Biography

Dr. Raja Gabaglia received her medical degree from the State University of Rio de Janeiro, Brazil (1984) where she specialized in immunology. She completed a postdoctoral fellowship in the Department of Immunology of San Martino Hospital at the University of Genoa, Italy (1991-1992). Dr. Raja Gabaglia held the position of Research Scholar at UCLA (1994 - 1997) and Research Scientist at La Jolla Institute for Allergy and Immunology (1997 - 2001) before joining Torrey Pines Institute for Molecular Studies in 2002. She is the current Director of the Laboratory of Vaccine Research in the Division of Immune Regulation.

Laboratory of Vaccine Research

Dr. Raja Gabaglia's research focuses on vaccine development for infectious diseases and cancer. The Laboratory of Vaccine Research studies the immune response to leishmaniasis, a common tropical parasitic disease transmitted by sand flies. Current projects are directed at understanding the mechanistic effects of a protective memory generated by a prime infection in murine models of the disease. An understanding of this protective phenotype is relevant to the generation of vaccines for all intracellular pathogens, including organisms like mycobacterium tuberculosis and leprae. Drs. Raja Gabaglia and Todd Braciak are developing a gene therapy using adenovirus vectors to prevent infection and spread of disease. Additional studies include induction of an immune response via administration of inhaled antigens and the effect of nasal priming on EAE – the animal model of multiple sclerosis.

Positions and Honors

• 1993-1994 Research Scientist. Ataulpho de Paiva Foundation, Rio de Janeiro, Brazil
• 1994-1997 Post-Doctoral Fellow. Dept. of Molecular Biology & Immunology,
  University of California, Los Angeles
• 1997-2001 Research Scientist. Division of Immune Regulation,
  La Jolla Institute for Allergy and Immunology
• 2001-present Assistant Member, Torrey Pines Institute for Molecular Studies, San Diego, CA

Societies and Professional Organizations

• Clinical Immunology Society
• American Association for the Advancement of Science
• American Society for Microbiology
• The American Association of Immunologists

Publications

1. Raja-Gabaglia, C., de Durana, Y., Graham, F., Gauldie, J., Sercarz, E., and Braciak, T. Attenuation of the glucocorticoid response during Ad5IL-12 adenovirus vector treatment enhances NK cell-mediated killing of MHC class I-negative LNCaP prostate tumors. Cancer Res. 67(5): 2290-7, 2007.

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2. Gabaglia, C.R., Sercarz, E.E., Diaz-De-Durana, Y., Hitt, M., Graham, F.L., Gauldie, J., Braciak, T.A. Life-long systemic protection in mice vaccinated with L. major and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes. Vaccine 23:247-257, 2004.
3. Melo, M.E., Stevens, D.B., Sercarz, E.E., Gabaglia, C.R. Nasal instillation of gpMBP can exacerbate murine EAE: effect of mucosal priming is an age-dependent phenomenon. J. Autoimmun. 22:13-20, 2004.
4. Ria, F., Gallard, A., Gabaglia, C.R., Guery, J.C., Sercarz, E.E., Adorini,L. Selection of similar naive T cell repertoires but induction of distinct T cell responses by native and modified antigen. J. Immunol. 172:3447-3453, 2004.

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5. Melo, M.E.F., Gabaglia, C.R., Mougdil, K.D., Sercarz, E.E., Quinn, A. Strain-dependent effect of nasal instillation of antigen on the immune response in mice. Isr. Med. Assoc. J. 4 (Supp 11):902-907, 2002.

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6. Gabaglia, C.R., Valle, M.T., Fenoglio, D., Barcinski, M.A., Manca, F. Cd4(+) T cell response to Leishmania spp. in non-infected individuals. Hum. Immunol. 61:531-537, 2000.
7. Maverakis, E., Mendoza, R., Southwood, S., Gabaglia, C.R., Abromson-Leeman, S., Campagnoni, A.T., Sette, A., Sercarz, E.E. Immunogenicity of self antigens is unrelated to MHC-binding affinity: T-cell determinant structure of Golli-MBP in the BALB/c mouse. J. Autoimmun. 15:315-322, 2000.

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8. Gabaglia, C.R., Pedersen, B., Hitt. M., Burdin, N., Sercarz, E.E., Graham, F.L., Gauldie, J., Braciak, T.A. A single intramuscular injection with an adenovirus-expressing IL-12 protects BALB/c mice against Leishmania major infection, while treatment with an IL-4-expressing vector increases disease susceptibility in B10.D2 mice. J. Immunol. 162:753-760, 1999.
9. Wang, R., Wang-Zhu, Y., Gabaglia, C.R., Kimachi, K., Grey, H.M. The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope. J. Exp Med. 190:983-94, 1999.

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10. Quinn, A., Gabaglia, C.R., Schneider, S.C., Braciak, T., Sercarz, E. Immune response. In: Encyclopedia of Immunology (2nd ed.)(Delves, P., Ed.), Academic Press, London, 1998.

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11. Gabaglia, C., Fenoglio, D., Valle, M.T., Telani, T., Romagnani, S., Manca, F. Phenotypes of human T cell lines generated against Leishmania from unprimed individuals. Eur. J. Histochem. 36:357-358, 1992.