Dr. Armishaw completed his undergraduate studies in Chemistry with honors in 1998 from the University of Melbourne, Australia, and his Ph.D. in Chemistry at the Institute for Molecular Bioscience within the University of Queensland, Australia, ("Controlling Cysteine Frameworks in Structurally Constrained Conotoxins") in 2003. Dr. Armishaw received the University of Queensland Graduate School Research Travel Award in 2001 and with the award, he spent a summer at the Scripps Research Institute in San Diego, CA. He also was awarded the Royal Australian Chemical Society / Bionomics award for the best Ph.D. thesis in biomolecular studies after completing his Ph.D. He then joined the University of Queensland as a post doctoral Research Officer under Professor Paul Alewood. For two years, Dr. Armishaw undertook post doctoral research at the Faculty of Pharmaceutical Sciences at the University of Copenhagen, Denmark with Professor Kristian Strømgaard. Dr. Armishaw has 11 publications and has contributed to one patent involving cyclised conotoxin peptides. His professional affiliations include the Royal Australian Chemical Institute and the American Peptide Society. Dr. Armishaw joined the Torrey Pines Institute in February 2008 as an Assistant Member.

Education

• 2003 - Doctor of Philosophy (Chemistry)
  Institute for Molecular Bioscience The University of Queensland, Brisbane, Australia
• 1998 - Bachelor of Science
  (Honours 1st Class) (Major Chemistry) Department of Chemistry
  The University of Melbourne, Australia

Positions

• Feb 2008 - Present
  Assistant Member Torrey Pines Institute for Molecular Studies, Port St Lucie, Florida
• Jan 2006 - Dec 2007
  DRA post-doctoral research fellow Department of Medicinal Chemistry Faculty of Pharmaceutical Sciences The University of Copenhagen, Denmark
• July 2003 - Dec 2005
  NHMRC research officer Institute for Molecular Bioscience The University of Queensland, Brisbane, Australia
• Jan 1999 - July 1999
  Research Assistant Department of Chemistry The University of Melbourne, Australia

Awards

• Travel award to the 20th American Peptide Symposium, Montreal, Canada, 2007.
• Bionomics best Ph.D. thesis award in biomolecular chemistry, 2003.
• Deans list, outstanding higher degree thesis, University of Queensland, 2003.
• 1st Prize, student oral presentation, Brisbane Biological and Organic Chemistry Symposium, 2001.
• University of Queensland Graduate School Research Travel Award, 2001.
• University of Queensland Graduate School Research Scholarship, 1999-2003.

Professional Affiliations

• Royal Australian Chemical Institute
• American Peptide Society

Conference Participation

• 20th American Peptide Symposium, Montreal, Canada, June 2007, Oral Presentation.
• Nordic Natural Products Conference 2007, Denmark, June 2007, Oral Presentation.
• 14th International Symposium on Medicinal Chemistry, Istanbul, Turkey, August 2006, Poster Presentation.
• 28th European Peptide Symposium, Prague, Czech Republic, September 2004, Poster Presentation.
• 27th European Peptide Symposium, Sorrento, Italy, September 2002, Poster Presentation.
• Oral Presentation - Brisbane Biological and Organic Chemistry Symposium, 30th November 2001, Oral Presentation.
• Oral and Poster Presentation - 17th American Peptide Symposium, San Diego CA, June 2001, Oral and Poster Presentation.

 

Publications

1. Muttenthaler, M, Nevin, ST, Grishin, AA, Ngo, ST, Choy, PT, Daly, NL, Hu, SH, Armishaw, CJ, Wang, CI, Lewis, RJ, Martin, JL, Noakes, PG, Craik, DJ, Adams, DJ, Alewood, PF. Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists. J Am Chem Soc. 132(10):3514-22, 2010.
2. 1. Armishaw, C.J.; Singh, N.; Medina-Franco, J.L.; Clark, R.J.; Scott, K.C.M.; Houghten, R.A.; Jensen, A.A., A Synthetic combinatorial strategy for developing α-conotoxin analogs as potent α₇ nicotinic acetylcholine receptor antagonists. J. Biol. Chem 285(3): 1809-21 2010
3. Armishaw, C.J.; Dutton, J.L.; Craik, D.J.; Alewood, P.F., Establishing regiocontrol of disulfide bond isomers of α-conotoxin ImI via the synthesis of N-to-C cyclic analogues. Biopolymers: Peptide Science. Epub Dec 2009. [Epub ahead of print]

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4. Armishaw, C.; Jensen, A.A.; Clark, R.J.; Balle, T.; Harpsoe, K. Skonberg, C.; Liljefors, T.; Strømgaard, K., Novel α-conotoxin analogues incorporating substituted proline derivatives: Improved antagonistic activity at the α₇ nicotinic acetylcholine receptor. J. Biol. Chem., (2009) 284: 9498-9512
5. Armishaw, C.J.; Jensen, A.A.; Skonberg, C.; Liljefors, T.; Strømgaard, K., Synthesis and biological activity of novel α-conotoxin analogues incorporating substituted proline derivatives. Adv. Exp. Med. Biol. (2009) 611:179-180

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6. Yan, W.X., Armishaw, C.J., Yang, Z., Cai, H., Alewood, P., Geczy, C. Mast cell and monocyte recruitment by S100A12 and its hinge domain. J. Biol. Chem. 283(19):13035-13043, 2008.

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7. Latham, C.F.; Hu, S.-H.; Gee, C.L.; Armishaw, C.J.; Alewood, P.F.; James, D.E.; Martin, J.L. Crystallization and preliminary X-ray diffraction of the Munc18c:Syntaxin41-29 complex. Acta Cryst. F. 2007. 63, 524-528.
8. Yang, Z.; Yan, W. X.; Cai, H..; Tedla, N.; Armishaw, C.J.; Di Girolamo, N.; Wang, H.W. ; Hampartzoumian, T.; Simpson, J.L.; Gibson, P.G.; Hunt, J.; Hart, P.;Hughes, J.M.; Perry, M.L.; Alewood, P.F.; Geczy, C.L. S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity. J Allergy Clin. Immunol. 2007, 119, 106-114.

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9. Armishaw, C.J.; Daly, N.L.; Nevin, S.T.; Adams, D.J.; Craik, D.J.; Alewood, P. F. α-Selenoconotoxins: A new class of potent a7 neuronal nicotinic receptor antagonists J. Biol. Chem. 2006, 281, 14136-14143.
10. Lovelace, E.S.; Armishaw, C.J.; Colgrave, M.L.; Wahlström, M.E.; Alewood, P.F.; Daly, N.L.; Craik, D.J. Cyclic MrIA: A stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter. J. Med. Chem. 2006, 49, 6561-6568.
11. Latham, C.F.; Lopez, J.A.; Hu, S.-H.; Gee, C.L.; Westbury, E.; Blair, D.H.; Armishaw, C.J.; Alewood, P.F.; Bryant, N.J.; James, D.E.; Martin, J.L. Molecular dissection of the Munc18c/Syntaxin4 interaction: Implications for regulation of membrane trafficking. Traffic, 2006, 7, 1408-1419.

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12. Armishaw, C.J.; Alewood, P.F. Conotoxins as research tools and drug leads, Current Protein Peptide Science 2005, 6, 221-240.

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13. Alewood, P.; Hopping, G.; Armishaw, C.J.; Marine toxins as a source of drug leads, Aust. J. Chem. 2003, 56, 769-774.

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14. Armishaw, C.J.; Dutton, J.L.; Lewis, R.J.; Craik, D.J.; Alewood, P.F. Controlling the cysteine framework of N-to-C cyclic analogues of α-conotoxin ImI. Peptides 2002. Proceedings of the 27th European Peptide Symposium, Sorrento, Italy, 2002, 20-21.

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15. Armishaw, C. J.; Alewood, P. F.; Rapid chemical protein synthesis, Today's Life Science, 2001, 13, 26-32.
16. Armishaw, C.J.; Dutton, J.L.; Hogg, R.C.; Adams, D.J.; Craik, D.J.; Alewood, P.F. Synthesis of N to C terminal cyclic analogues of α-conotoxin ImI by chemoselective ligation of unprotected linear precursors. Peptides: The Wave of the Future, Proceedings of the 17th American Peptide Symposium, San Diego, USA 2001 113-114.

Patents

1. Craik, D.J., Daly, N.L., Nielsen, K.J., Armishaw, C.J., Clark, R.J., Alewood, P.F.; Cyclised conotoxin peptides U.S. Pat. Appl. Publ. 2005 44pp., Continuation in part of U.S. Ser. No. 787,082.