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CALIFORNIA SCIENTISTS James Binley Todd Braciak Yang D. Dai Joanna Davies Brigitte Dudouet Richard A. Houghten Tony Hugli Valeria Judkowski J. Patrick Kampf Sophia Khaldoyanidi Alan Kleinfeld Prasad Koka Vipin Kumar Eugene G. Levin David Loskutoff Adel Nefzi Ron Ogata Clemencia Pinilla Claudia Raja Gabaglia Roy Riblet Fahu Samad Sally Sarawar Eli Sercarz Ingrid Schraufstatter Darcy Wilson FLORIDA SCIENTISTS Christopher Armishaw Colette Dooley Marc Giulianotti Richard A. Houghten Jose Luis Medina-Franco Karina Martinez Mayorga

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Dr. Armishaw completed his undergraduate studies in Chemistry with honors in 1998 from the University of Melbourne, Australia, and his Ph.D. in Chemistry at the Institute for Molecular Bioscience within the University of Queensland, Australia, ("Controlling Cysteine Frameworks in Structurally Constrained Conotoxins") in 2003. Dr. Armishaw received the University of Queensland Graduate School Research Travel Award in 2001 and with the award, he spent a summer at the Scripps Research Institute in San Diego, CA. He also was awarded the Royal Australian Chemical Society / Bionomics award for the best Ph.D. thesis in biomolecular studies after completing his Ph.D. He then joined the University of Queensland as a post doctoral Research Officer under Professor Paul Alewood. For two years, Dr. Armishaw undertook post doctoral research at the Faculty of Pharmaceutical Sciences at the University of Copenhagen, Denmark with Professor Kristian Strømgaard. Dr. Armishaw has 11 publications and has contributed to one patent involving cyclised conotoxin peptides. His professional affiliations include the Royal Australian Chemical Institute and the American Peptide Society. Dr. Armishaw joined the Torrey Pines Institute in February 2008 as an Assistant Member.

Research Focus

Dr. Armishaw specializes in the discovery of new compounds for the treatment of pain based on those found in venomous marine snails using synthetic combinatorial chemistry techniques.

Awards

• Travel award to the 20th American Peptide Symposium, Montreal, Canada, 2007.
• Bionomics best Ph.D. thesis award in biomolecular chemistry, 2003.
• Deans list, outstanding higher degree thesis, University of Queensland, 2003.
• 1st Prize, student oral presentation, Brisbane Biological and Organic Chemistry Symposium, 2001.
• University of Queensland Graduate School Research Travel Award, 2001.
• University of Queensland Graduate School Research Scholarship, 1999-2003.

Professional Affiliations

Royal Australian Chemical Institute
American Peptide Society

Conference Participation

1. 20th American Peptide Symposium, Montreal, Canada, June 2007, Oral Presentation.
2. Nordic Natural Products Conference 2007, Denmark, June 2007, Oral Presentation.
3. 14th International Symposium on Medicinal Chemistry, Istanbul, Turkey, August 2006, Poster Presentation.
4. 28th European Peptide Symposium, Prague, Czech Republic, September 2004, Poster Presentation.
5. 27th European Peptide Symposium, Sorrento, Italy, September 2002, Poster Presentation.
6. Oral Presentation - Brisbane Biological and Organic Chemistry Symposium, 30th November 2001, Oral Presentation.
7. Oral and Poster Presentation - 17th American Peptide Symposium, San Diego CA, June 2001, Oral and Poster Presentation.

Publications

1. Yan, W.X.; Armishaw, C.J.; Yang, Z.; Cai, H.; Alewood, P.; Geczy, C. Mast cell and monocyte recruitment by S100A12 and its hinge domain. J. Biol. Chem. 2008. Accepted for Publication.
2. Latham, C.F.; Hu, S.-H.; Gee, C.L.; Armishaw, C.J.; Alewood, P.F.; James, D.E.; Martin, J.L. Crystallization and preliminary X-ray diffraction of the Munc18c:Syntaxin41-29 complex. Acta Cryst. F. 2007. 63, 524-528.
3. Yang, Z.; Yan, W. X.; Cai, H..; Tedla, N.; Armishaw, C.J.; Di Girolamo, N.; Wang, H.W. ; Hampartzoumian, T.; Simpson, J.L.; Gibson, P.G.; Hunt, J.; Hart, P.;Hughes, J.M.; Perry, M.L.; Alewood, P.F.; Geczy, C.L. S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity. J Allergy Clin. Immunol. 2007, 119, 106-114
4. Armishaw, C.J.; Daly, N.L.; Nevin, S.T.; Adams, D.J.; Craik, D.J.; Alewood, P. F. a-Selenoconotoxins: A new class of potent a7 neuronal nicotinic receptor antagonists J. Biol. Chem. 2006, 281, 14136-14143.
5. Lovelace, E.S.; Armishaw, C.J.; Colgrave, M.L.; Wahlström, M.E.; Alewood, P.F.; Daly, N.L.; Craik, D.J. Cyclic MrIA: A stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter. J. Med. Chem. 2006, 49, 6561-6568.
6. Latham, C.F.; Lopez, J.A.; Hu, S.-H.; Gee, C.L.; Westbury, E.; Blair, D.H.; Armishaw, C.J.; Alewood, P.F.; Bryant, N.J.; James, D.E.; Martin, J.L. Molecular dissection of the Munc18c/Syntaxin4 interaction: Implications for regulation of membrane trafficking. Traffic, 2006, 7, 1408-1419.
7. Armishaw, C.J.; Alewood, P.F. Conotoxins as research tools and drug leads, Current Protein Peptide Science 2005, 6, 221-240.
8. Latham, C.F.; Lopez, J.A.; Hu, S.-H.; Gee, C.L.; Westbury, E.; Blair, D.H.; Armishaw, C.J.; Alewood, P.F.; Bryant, N.J.; James, D.E.; Martin, J.L. Molecular dissection of the Munc18c/Syntaxin4 interaction: Implications for regulation of membrane trafficking. Traffic, 2006, 7, 1408-1419.
9. Alewood, P.; Hopping, G.; Armishaw, C.J.; Marine toxins as a source of drug leads, Aust. J. Chem. 2003, 56, 769-774.
10. Armishaw, C.J.; Dutton, J.L.; Lewis, R.J.; Craik, D.J.; Alewood, P.F. Controlling the cysteine framework of N-to-C cyclic analogues of a-conotoxin ImI. Peptides 2002. Proceedings of the 27th European Peptide Symposium, Sorrento, Italy, 2002, 20-21.
11. Armishaw, C. J.; Alewood, P. F.; Rapid chemical protein synthesis, Today's Life Science, 2001, 13, 26-32.
12. Armishaw, C.J.; Dutton, J.L.; Hogg, R.C.; Adams, D.J.; Craik, D.J.; Alewood, P.F. Synthesis of N to C terminal cyclic analogues of a-conotoxin ImI by chemoselective ligation of unprotected linear precursors. Peptides: The Wave of the Future, Proceedings of the 17th American Peptide Symposium, San Diego, USA 2001 113-114.

Patents

1. Craik, D.J., Daly, N.L., Nielsen, K.J., Armishaw, C.J., Clark, R.J., Alewood, P.F.; Cyclised conotoxin peptides U.S. Pat. Appl. Publ. 2005 44pp., Continuation in part of U.S. Ser. No. 787,082.