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CALIFORNIA SCIENTISTS James Binley Todd Braciak Yang D. Dai Joanna Davies Brigitte Dudouet Richard A. Houghten Tony Hugli Valeria Judkowski J. Patrick Kampf Sophia Khaldoyanidi Alan Kleinfeld Prasad Koka Vipin Kumar Eugene G. Levin David Loskutoff Adel Nefzi Ron Ogata Clemencia Pinilla Claudia Raja Gabaglia Roy Riblet Fahu Samad Sally Sarawar Eli Sercarz Ingrid Schraufstatter Darcy Wilson FLORIDA SCIENTISTS Christopher Armishaw Colette Dooley Marc Giulianotti Richard A. Houghten Jose Luis Medina-Franco Karina Martinez Mayorga

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Education

• Ph.D., Biology, University of Wisconsin-Milwaukee, WI, 1990
• M.S., Biology, University of Maine- Orono, MA, 1984
• B.S., Biology, University of Colombo-Sri Lanka, 1980, first class honors

Academic Positions

• Aug 2006-present - Associate Member
  Torrey Pines Institute for Molecular Studies, San Diego, CA
• July 2004 - July 2006 - Associate Professor,
  La Jolla Institute for Molecular Medicine, San Diego, CA
• Jan 1999 - July 2004 - Assistant Professor, Dept. of Cell Biology, division of Vascular Biology,
  The Scripps Research Institute, La Jolla, CA
• Nov 1996 - Jan 1999 - Senior Research Associate,
  The Scripps Research Institute, La Jolla, CA
• Nov 1992 - Nov 1996 - Research Associate,
  The Scripps Research Institute, La Jolla, CA
• Nov 1989 - Nov 1992 - Postdoctoral Fellow, Dept. of Health and Biological Sciences,
  University of Wisconsin, Milwaukee, Wisconsin
• Sept 1989 - May 1990 - Associate Lecturer, Dept. of Biological Sciences, University of Wisconsin,
  Milwaukee, Wisconsin
• Sept 1984 - Sept 1989 - Teaching Assistant/Research Assistant, Dept. of Biological Sciences,
  University of Wisconsin, Milwaukee, Wisconsin
• Sept 1982 - Aug 1984 - Research Assistant, Cooperative Fisheries Research Unit,
  University of Maine, Orono, Maine
• Sept 1980 - Aug 1982 Assistant Lecturer/Research Assistant, Dept. of Biology,
  University of Colombo, Sri Lanka

Honors and Awards

• Fullbright Fellow, USIA and the Institute of International Education, Washington, D.C. August 1982
• University of Maine-Orono. Cooperative Fisheries Research Unit. Tuition Scholarship, 1982
• University of Wisconsin-Milwaukee. Non-resident tuition scholarship, August 1984
• Poster award (2nd place) 119th Ann. Meeting, Amer. Fisheries Soc., September 4-8, 1989, Anchorage, AK
• American Heart Association Postdoctoral Fellowship Award, July 9, 1994
• Invited Speaker, VIth International Workshop on the Molecular and Cellular Biology of Plasminogen Activation, November 1-5, 1997, San Diego, CA
• Invited Speaker, Gordon Conference on Vascular Cell Biology, June 23-28, 1996
  Proctor Academy, Andover, NH
• Invited Speaker, Gordon Conference on Atherosclerosis, June 15-20, 1997
  Kimball Union Academy, Meriden, NH

Publications

1. Amrani, D.L., Rosenberg, J., Samad, F., Bergtrom, G. and Banfield, D.K. (1993). Developmental expression of chicken antithrombin III is regulated by increased RNA abundance and intracellular processing. Biochem. Biophys. Acta. 1171:239-246.
2. Samad, F., Bergtrom, G., Eissa, H. and Amrani, D.L. (1993). Stimulation of chick hepatocyte fibronectin production by fibroblast-conditioned medium is due to interleukin-6. Biochem. Biophys. Acta. 118: 207-213.
3. Samad, F., Bergrtrom, G. and Amrani, D.L. (1994). Regulation of plasminogen activation by interleukin-6 in human lung fibroblasts. Biochem. Biophys. Acta. 1221:307-314.
4. Samad, F., Bergtrom, G., Lelkes, P.I., Rajappa, V. and Amrani, D.L. (1995). Differential-cytokine regulation of PAI-1 gene expression in human endothelial cells. Endothelium 3:243-252.
5. Trewitt, M.P., Luhm, R.A., Samad, F., Ramakrishnan, S., Kao, W.-Y. and Bergtrom, G. (1995). Molecular evolutionary analysis of the YWVZ/7B globin gene cluster of the insect Chrironomous thummi. J. Mol. Evol. 41:313-328.
6. Fearns, C., Samad, F. and Loskutoff, D.J. (1996). Synthesis and localiztion of PAI-1 in the vessel wall. In: Vascular Control and Homeostasis. Advances in Vascular Biology, Vadas, M. and Harlan, J. (eds). Gordon and Breach Publishers, Camberwell, Victoria, Australia p. 207-226.
7. Samad, F., Yamamoto, K. and Loskutoff, D.J. (1996). Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo: Induction by tumor necrosis factor-a and lipopolysaccharide. J. Clin. Invest. 97:37-46.
8. Samad, F. and Loskutoff, D.J. (1996). Tissue distribution and regulation of plasminogen activator inhibitor 1 in obese mice. Mol. Med. 2:568-582.
9. Samad, F., Yamamoto, K., Pandey, M. and Loskutoff, D.J. (1997). Elevated expression of transforming growth factor-ß in adipose tissue from obese mice. Mol. Med. 3:37-48.
10. Samad, F. and Loskutoff, D.J. (1997). The fat mouse: A powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM. Thromb Haemost, 78:652-655.
11. Samad, F., Schneiderman, J. and Loskutoff. (1997). Expression of fibrinolytic genes in tissues from human atherosclerotic aneurysms and from obese mice. Ann. NY Acad. Sci. 811:350-360.
12. Samad, F. and Loskutoff, D.J. (1998). The adipocyte and hemostatic balance in obesity: Studies of PAI-1. Arterioscler Thromb Vasc Biol. 18:1-6.
13. Samad, F., Pandey, M. and Loskutoff, D.J. (1998). Tissue factor gene expression in the adipose tissues of obese mice. Proc. Natl. Acad. Sci. USA. 95:7591-7599.
14. Samad, F., Hotamisligil, G.S., Uysal, K.T., Pandey, M., Weisbrock, S.M. and Loskutoff, D.J. (1999). Tumor Necrosis Factor-a: A key component in the obesity-linked elevation of plasminogen activator inhibitor-1. Proc. Natl. Acad. Sci. USA 96:6902-6907.
15. Samad, F. and Loskutoff, D.J. (1999). Hemostatic gene Expression and Vascular Disease in Obesity: Insights from studies of Genetically Obese Mice. Thromb Haemost 82(2)742-747
16. Loskutoff, D.J., Ihara, I., Yamamoto, K. and Samad, F. (2000). The Fat mouse: A powerful genetic model to study hemostatic gene expression in obesity. In New Frontier in Vascular Biology; Thrombosis and Hemostasis, Suzuki, K., Ikeda, Y. and Maruyama, I. (ed.) Eibun Press, Ltd., Osaka, Japan.
17. Loskutoff, D.J. and Samad, F. Mechanisms of elevated plasminogen activator inhibitor 1 in obesity. Takada, A. (ed.) In: Excerpta Medica International Congress Series (ICS), Elsevier Science, 1997.
18. Loskutoff, D.J., Fujisawa, k., and Samad, F. (2000). The fat mouse: A powerful genetic model to study hemostatic gene expression in obesity/NIDDM. Annals N.Y. Acad. Sci. 902: 272-282.
19. Samad, F., Pandey M. Bell, P.A., and Loskutoff, D.J. (2000) Insulin continues to induce plasminogen activator inhibitor 1 gene expression in insulin-resistant mice and adipocytes. Molecular Medicine . Mol. Med. 6:680-692.
20. Samad, F., Pandey, M and Loskutoff, D.J. (2001). Regulation of tissue factor gene expression in obesity. Blood. 98:3353-3358.
21. Pandey, M., Uysal, K.T., Tuncman, G., Hotamisligil, G.S., and Samad, F. (2003). Divergent roles for p55 and p75 TNF- receptors in the induction of plasminogen activator inhibitor-1. Am.J.Pathol. 162:933-941.
22. Pandey, M., Loskutoff, D.J, and Samad, F. (2005). Molecular mechanisms of tumor necrosis factor-a-mediated plasminogen activator inhibitor-1 expression in adipocytes. The FASEB Journal express article 10.1096/fj.04-3459fje.Published online June16.
23. Jaap G. Neels, Manjula Pandey, Gökhan S. Hotamisligil, and Fahumiya Samad (2006). Auto-amplification of TNF-a: A potential mechanism for the maintenance of elevated TNF-a in male but not female obese mice. Am. J. Pathol. 168:435-444.
24. Samad F, Hester KD, Yang G, Hannun, YA, Bielawski, J. (2006) Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes, 55:2579-2587.
25. Samad F. (2007). Contribution of sphingolipids to the pathogenesis of obesity. Future Lipid, 2(6)625-639