Torrey Pines Institute for Molecular Studies science image
Torrey Pines Institute for
Molecular Studies
3550 General Atomics Court, 2-129
San Diego, CA 92121-1122
USA
Scientists
Fahumiya Samad
Associate Member

858.597.3812 - phone
858.597.3804 - fax
contact by email

Education

  • Ph.D., Biology, University of Wisconsin-Milwaukee, WI, 1990
  • M.S., Biology, University of Maine- Orono, ME, 1984
  • B.S., Biology, University of Colombo-Sri Lanka, 1980, first class honors

Academic Positions

  • Aug 2006-present - Associate Member
    Torrey Pines Institute for Molecular Studies, San Diego, CA
  • July 2004 - July 2006 - Associate Professor,
    La Jolla Institute for Molecular Medicine, San Diego, CA
  • Jan 1999 - July 2004 - Assistant Professor, Dept. of Cell Biology, division of Vascular Biology,
    The Scripps Research Institute, La Jolla, CA
  • Nov 1996 - Jan 1999 - Senior Research Associate,
    The Scripps Research Institute, La Jolla, CA
  • Nov 1992 - Nov 1996 - Research Associate,
    The Scripps Research Institute, La Jolla, CA
  • Nov 1989 - Nov 1992 - Postdoctoral Fellow, Dept. of Health and Biological Sciences,
    University of Wisconsin, Milwaukee, Wisconsin
  • Sept 1989 - May 1990 - Associate Lecturer, Dept. of Biological Sciences, University of Wisconsin,
    Milwaukee, Wisconsin
  • Sept 1984 - Sept 1989 - Teaching Assistant/Research Assistant, Dept. of Biological Sciences,
    University of Wisconsin, Milwaukee, Wisconsin
  • Sept 1982 - Aug 1984 - Research Assistant, Cooperative Fisheries Research Unit,
    University of Maine, Orono, Maine
  • Sept 1980 - Aug 1982 Assistant Lecturer/Research Assistant, Dept. of Biology,
    University of Colombo, Sri Lanka

Honors and Awards

  • Fulbright Fellow, USIA and the Institute of International Education, Washington, D.C. August 1982
  • University of Maine-Orono. Cooperative Fisheries Research Unit. Tuition Scholarship, 1982
  • University of Wisconsin-Milwaukee. Non-resident tuition scholarship, August 1984
  • Poster award (2nd place) 119th Ann. Meeting, Amer. Fisheries Soc., September 4-8, 1989, Anchorage, AK
  • American Heart Association Postdoctoral Fellowship Award, July 9, 1994
  • Invited Speaker, VIth International Workshop on the Molecular and Cellular Biology of Plasminogen Activation, November 1-5, 1997, San Diego, CA
  • Invited Speaker, Gordon Conference on Vascular Cell Biology, June 23-28, 1996
    Proctor Academy, Andover, NH
  • Invited Speaker, Gordon Conference on Atherosclerosis, June 15-20, 1997
    Kimball Union Academy, Meriden, NH

Publications

  1. Samad, F, Badeanlou, L, Shah, C, Yang, G. Adipose tissue and ceramide biosynthesis in the pathogenesis of obesity. In: Sphingolipids and Metabolic Disease, Landes Bioscience, 2010.
  2. Hu, W., Bielawski, J., Samad, F., Merril, A.H. Jr., Cowart, L.A. Palmitate increases sphingosine phosphate 1 in C2C12 myotubes via upregulation of sphingosine kinase message and activity. J. Lipid Res. Epub Apr 15, 2009. [Epub ahead of print.]
  3. Neels, G.N., Badeanlou, L., Hester, K.D., Samad, F. Keratinocyte-derived Chemokine in Obesity: Expression and Role in Adipose Macrophage Infiltration and Glucose Homeostasis. J. Biol. Chem. Jun 3, 2009. [Epub ahead of print.]
  4. Yang, G., Badeanlou, L., Bielawski, J., Hannun, Y.A., Samad, F. Central role for ceramide biosynthesis in body weight regulation, energy metabolism and the metabolic syndrome. Am. J. Physiol. Endocrinol. Metab. 297(1):E211-24, 2009. Epub May 12, 2009.
  5. Shah, C., Yang, C., Lee, I., Bielawski, J., Hannun, Y.A. and Samad, F. Protection from High Fat Diet Induced Increase in Ceramide in Mice Lacking Plasminogen Activator Inhibitor-1. J. Biol. Chem. 283:13538-13548, 2008.
  6. Samad, F. Contribution of sphingolipids to the pathogenesis of obesity. Future Lipidology, 2(6):625-639, 2007.
  7. Shah, C., Lee, I.,Bielawski, J., Hannun, Y.A., Samad, F. A novel role for plasminogen activator inhibitor 1 in ceramide metabolism: a potential molecular link between obesity, PAI-1, insulin resistance and cardiovascular risk. submitted, Circulation, 2007.
  8. Neels, J.G., Pandey, M, Hotamisligil, G.S., Samad, F. Auto-amplification of TNF-α A potential mechanism for the maintenance of elevated TNF-α in male but not female obese mice. American Journal of Pathology 168(2):435-444, 2006.
  9. Samad, F., Hester, K., Yang, G., Hannun, Y.A., Bielawski, J. Altered adipose and plasma sphinolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes, 55:2579-2587, 2006.
  10. Pandey, M., Loskutoff, D.J., Samad, F. Molecular mechanisms of tumor necrosis factor α-mediated plasminogen activator in ihibitor-1 expression in adipocytes. The FASEB Journal express article 10.1096/fj.04-3459fje, 2005.
  11. Pandey, M., Loskutoff, D.J., Samad, F. Molecular mechanisms of tumor necrosis factor-α-mediated plasminogen activator inhibitor-1 expression in adipocytes. The FASEB Journal express article 10.1096/fj.04-3459fje. Published online May 31 (2005).
  12. Pandey, M., Uysal, K.T., Tuncman, G., Hotamisligil, G.S., and Samad, F. Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen activator inhibitor-1. AM.J.Pathol. 162:933-941, 2003.
  13. Samad, F., Pandey, M and Loskutoff, D.J. Regulation of tissue factor gene expression in obesity. Blood 98(12):3353-3358, 2001.
  14. Loskutoff, D.J., Fujisawa, K., Samad, F. The fat mouse: A powerful genetic model to study hemostatic gene expression in obesity/NIDDM. Atherosclerosis V; The Fifth Saratoga International Conference. Fujio Numano, Michael A. Gimbrone, Jr. (eds). Annals N.Y. Acad. Sci. Vol. 902: 272-282, 2000.
  15. Loskutoff, D.J., Ihara, I., Yamamoto, K., Samad, F. The Fat mouse: A powerful genetic model to study hemostatic gene expression in obesity. New Frontier in Vascular Biology; Thrombosis and Hemostasis, Suzuki, K., Ikeda, Y. and Maruyama, I. (ed.) Eibun Press, Ltd., Osaka, Japan, 2000.
  16. Samad, F., Pandey M., Bell, P.A., Loskutoff, D.J. Insulin continues to induce plasminogen activator inhibitor 1 gene expression in insulin-resistant mice and adipocytes. Mol. Med. 6: 680-692, 2000.
  17. Samad, F. and Loskutoff, D.J. Hemostatic gene expression and vascular disease in obesity: Insights from studies of genetically obese mice. Thromb. Haemost. 82:742-747, 1999.
  18. Samad, F., Hotamisligil, G.S., Uysal, K.T., Pandey, M., Weisbrock, S.M. and Loskutoff, D.J. Tumor Necrosis Factor-a: A key component in the obesity-linked elevation of plasminogen activator inhibitor-1. Proc. Natl. Acad. Sci. USA 96:6902-6907, 1999.
  19. Samad, F., Uysal, K.T., Wiesbrock, S.M., Pandey, M., Hotamisligil, G.S., Loskutoff, D.J. Tumor necrosis factor-α is a key component in the obesity-linked elevation of plasminogen activator inhibitor-1. Proc. Natl. Acad. Sci. USA. 96:6902-6907, 1999.
  20. Loskutoff, D.J. and Samad, F. The adipocyte and hemostatic balance in obesity: Studies of plasminogen activator inhibitor 1. Arterioscler Thromb Vasc BioI. 18: 1-6, 1998.
  21. Samad, F. and Loskutoff, D.J. The adipocyte and hemostatic balance in obesity: Studies of PAI-1. Arterioscler Thromb Vasc Biol. 18:1-6, 1998.
  22. Samad, F., Pandey, M., Loskutoff, D.J. Tissue factor gene expression in the adipose tissues of obese mice. Proc. Natl. Acad. Sci. USA. 95:7591-7596, 1998.
  23. Loskutoff, D.J. and Samad, F. Mechanisms of elevated plasminogen activator inhibitor 1 in obesity. Takada, A., Collen, D., Gaffney, P.J. eds. Recent Progress in Blood Coagulation and Fibrinolysis; International Congress Series 1129, EXCERPTA MEDICA ELSEVIER, pp 221-227, 1997.
  24. Loskutoff, D.J. and Samad, F. Mechanisms of elevated plasminogen activator inhibitor 1 in obesity. Takada, A. (ed.) Excerpta Medica International Congress Series (ICS), Elsevier Science, 1997.
  25. Samad, F. and Loskutoff, D.J. The fat mouse: A powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM. Thromb. Haemost. 78:652-655, 1997.
  26. Samad, F., Schneiderman, J., Loskutoff, D.J. Expression of fibrinolytic genes in tissues from human atherosclerotic aneurysms and from obese mice. Ann. NY Acad. Sci. 811,350-360, 1997.
  27. Samad, F., Yamamoto, K., Pandey, M., Loskutoff, D.J. Elevated expression of transforming growth factor-β in adipose tissue from obese mice. Mol. Med. 3:37-48, 1997.
  28. Fearns, C., Samad, F., Loskutoff, D.J. Synthesis and localization of PAI-1 in the vessel wall. Vascular Control of Hemostasis. Advances in Vascular Biology, Vadas, M., Harlan, J. (eds). Gordon and Breach Publishers, Camberwell, Victoria, Australia p. 207- 226, 1996.
  29. Samad, F. and Loskutoff, D.J. Tissue distribution and regulation of plasminogen activator inhibitor 1 in obese mice. Mol. Med. 2:568-582, 1996.
  30. Samad, F., Yamamoto, K. and Loskutoff, D.J. Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo: Induction by tumor necrosis factor-a and lipopolysaccharide. J. Clin. Invest. 97:37-46, 1996.
  31. Samad, F., Bergtrom, G., Lelkes, P.I., Rajappa, V. and Amrani, D.L. Differential-cytokine regulation of PAI-1 gene expression in human endothelial cells. Endothelium 3:243-252, 1995.
  32. Trewitt, M.P., Luhm, R.A., Samad, F., Ramakrishnan, S., Kao, W.-Y. and Bergtrom, G. Molecular evolutionary analysis of the YWVZ/7B globin gene cluster of the insect Chrironomous thummi. J. Mol. Evol. 41:313-328, 1995.
  33. Samad, F., Bergrtrom, G. and Amrani, D.L. Regulation of plasminogen activation by interleukin-6 in human lung fibroblasts. Biochem. Biophys. Acta. 1221:307-314, 1994.
  34. Amrani, D.L., Rosenberg, J., Samad, F., Bergtrom, G. and Banfield, D.K. Developmental expression of chicken antithrombin III is regulated by increased RNA abundance and intracellular processing. Biochem. Biophys. Acta. 1171:239-246, 1993.
  35. Samad, F., Bergtrom, G., Eissa, H. and Amrani, D.L. Stimulation of chick hepatocyte fibronectin production by fibroblast-conditioned medium is due to interleukin-6. Biochem. Biophys. Acta. 118: 207-213, 1993.
  36. Samad, F. and Stanley, J.G. Loss of freshwater shellfish after water drawdown in Lake Sebasticook, Maine. J. Fresh. Ecol. 3:519-523, 1986.
Copyright © 2010 Torrey Pines Institute for Molecular Studies. All rights reserved.