Torrey Pines Institute for Molecular Studies science image
Torrey Pines Institute for
Molecular Studies
3550 General Atomics Court, 2-129
San Diego, CA 92121-1122
USA
Scientists
Ingrid Schraufstatter
Associate Member
Immunology

858.597.3898 - phone
858.597.3804 - fax
contact by email

Dr. Schraufstatter earned her M.D. from the University of Aachen in Germany and completed her studies in pharmacology at King's College in London, UK and in immunology at the Scripps Research Institute in La Jolla, CA. She was an Assistant Professor at the Scripps Research Institute in La Jolla, CA from 1989 - 1999 in the Department of Immunology and a Professor from 1999 - 2007 in the Division of Cancer Biology at the La Jolla Institute for Molecular Medicine in San Diego, CA. Dr. Schraufstatter is an Adjunct Member in the Immunology Department at the Torrey Pines Institute for Molecular Studies.

Research Focus

Dr. Schraufstatter's research focuses on the role of chemokines and the anaphylatoxins C3a and C5a on cell signaling and migration of leukocytes, and has over the last several years expanded to the effect of these chemotactic factors on stem cells.

Professional Affiliations

  • Ad hoc reviewer for NIH, TTT and VMD study sections, 1992-4, 2005, 2006.
  • Peer Review Member, Western Review Consortium, American Heart Association, 2006 - present.
  • Juror, AHA Young Investigator award, Western States, 2007.
  • Associate Editor: American Journal of Physiology, Lung Cell Molecular Physiology.
  • Reviewer for: Journal of Biological Chemistry, Journal of Immunology, Journal of Clinical Investigation, (please write out) Cancer Res., Blood, and others.

Publications

  1. Zhang, Z, Cherryholmes, G, Chang, F, Rose, DM, Schraufstatter, I, Shively, JE. Evidence that cathelicidin peptide ll-37 may act as a functional ligand for cxcr2 on human neutrophils. Eur J Immunol. Epub Sept 11, 2009. [Epub ahead of print]
  2. Schraufstatter, I.U., DiScipio, R.G., Zhao, M., Khaldoyanidi, S.K. C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation. J. Immunol. 182(6):3827-36, 2009.
  3. Hartmann, T.N., Leick, M., Ewers, S., Diefenbacher, A., Schraufstatter, I., Honczarenko, M., Burger, M. Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner. Immunology. 125(2):252-62, 2008. Epub Apr 4, 2008.
  4. Orlovskaya, I., Schraufstatter, I., Loring, J. and Khaldoyanidi, S. Hematopoietic differentiation of embryonic stem cells. Methods 45:159-167, 2008.
  5. DiScipio, R.G. and Schraufstatter, I.U. The role of the complement anaphylatoxins in the recruitment of Eosinophils. Int. Immunopharmacol. 7:1909-23, 2007.
  6. Serobyan, N., Jagannathan, S., Orlovskaya, I., Schraufstatter, I.U., Loring, J., Skok, M. Khaldoyanidi, S.K. The Cholinergic System is involved in Regulation of the Development of the Hematopoietic System. Life Sci. 80(24-25):2352-60, 2007.
  7. Zhao, M., Mueller, B.M., Discipio, R.G., Schraufstatter, I.U. Akt plays an important role in breast cancer cell chemotaxis to CXCL12. Breast Cancer Res Treat. Aug 9, 2007.
  8. DiScipio, R.G., Schraufstatter, I.U., Sikora, L, Zuraw, B.L., Sriramarao, P. C5a mediates secretion and activation of matrix metalloproteinase 9 from human eosinophils and neutrophils. Int. Immunopharmacol. 6:1109-1118, 2006.
  9. Mueller, F.J., Serobyan, N., Schraufstatter, I.U., DiScipio, R.G., Loring, J.F., Snyder, E.Y., Khaldoyanidi, S.K. Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins. Stem Cells, 24:2367-72, 2006.
  10. Wimmer, A., Khaldoyanidi, S.K., Judex, M., Serobyan, N., Discipio, R.G., Schraufstatter, I.U. CCL18/PARC stimulates hematopoiesis in long-term bone-marrow cultures indirectly through its effect on monocytes. Blood. 108:3722-3729, 2006.
  11. Zhao, M., DiScipio, R., Wimmer, A., Schraufstatter, I.U. Regulation of CXCR4-mediated nuclear translocation of ERK1/2. Mol. Pharmacol. 69:66-75, 2006.
  12. Burger, M., Hartmann, T., Burger, J.A., Schraufstatter, I.U. KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway. Oncogene, 24:2067-2075, 2005.
  13. Liu-Bryan, R., Pay, S., Schraufstatter, I.U., Rose, D.M. The CXCR1 tail mediates ƒÒ1-integrin dependent cell migration via MAP kinase signaling, Biochem. Biophys. Res. Commun. 332:117-125, 2005.
  14. Serobyan, N., Schraufstatter, I.U., Strongin, A., Khaldoyanidi, S.K. Nicotinic acetylcholine receptor-mediated activation of endothelial cells results in the arrest of hematopoietic progenitor cells on endothelium. Brit. J. Haematol. 129:257-265, 2005.
  15. Schraufstatter, I.U., Takamori, H., Sikora, L., Sriramarao, P., DiScipio, R.D. Eosinophils and monocytes produce pulmonary and activation regulated chemokine (PARC/CCL18), which activates cultured monocytes/macrophages Am. J. Physiol. Lung Cell Mol. Physiol., 286:L494-L501, 2004.
  16. Zhao, M., Wimmer, A., Trieu, K., DiScipio, R.G., Schraufstatter, I.U. Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2. J. Biol. Chem. 279:49259-49267, 2004.
  17. Mockenhaupt, M., Peters, F., Schwenk-Davoine, I., Herouy, Y., Schraufstatter, I.U., Elsner, P., Norgauer, J. Evidence of involvement of CXC-chemokines in proliferation of cultivated human melanocytes. Int. J. Mol. Med., 12:597-601, 2003.
  18. Schraufstatter, I.U., Trieu, K., Rose, D., Terkeltaub, R.A., Burger, M. IL-8 mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the EGF-receptor. J. Immunol., 171:6714-6722, 2003.
  19. Schraufstatter, I.U., Trieu, K., Sikora, L., Sriramarao, P., DiScipio, R.D. Complement C3a and C5a induce different signal transduction cascades in endothelial cells. J. Immunol. 169:2102-2110, 2002.
  20. Schraufstatter, I.U., Chung, J., Burger, M. IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways. Am. J. Physiol. Lung Cell Mol. Physiol., 280:L1094-L1103, 2001.
  21. Browning, D.D., Diehl, W.C., Hsu, M.H., Schraufstatter, I.U., Ye, R.D. Autocrine regulation of interleukin-8 production in human monocytes. Am J Physiol Lung Cell Mol Physiol. 279(6):L1129-36, 2000.
  22. Takamori, H., Oades, Z.G., Burger, M., Schraufstatter, I.U. Autocrine growth effect of IL-8 and gro-Ą on a human pancreatic cancer cell line, CAPAN 1. Pancreas, 21:52-56, 2000.
  23. Burger, M., Burger, J.A., Hoch, R.C., Oades, Z., Takamori, H., Schraufstatter, I.U. Point mutation causing constitutive signaling of the CXCR2 leads to transforming activity similar to KSRV-GPCR. J. Immunol., 163:2017-2022, 1999.
  24. Metzner, B., Hofmann, C., Heinemann, C., Zimpfer, U., Schraufstatter, I.U., Schopf, E., Norgauer, J. Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431 Oncol. Rep., 6:1405-1410, 1999.
  25. Cochrane, C.G., Revak, S.D., Merritt, T.A., Schraufstatter, I.U., Hoch, R.C., Henderson, C., Andersson, S., Takamori, H., Oades, Z.G. Bronchoalveolar lavage with KL4-surfactant in models of meconium aspiration syndrome. Pediatr Res. Nov;44:705-15, 1998.
  26. DiScipio, R.G., Daffern, P., Schraufstatter, I.U., Sriramarao, P. Human polymorphonuclear leukocytes adhere to complement factor H through an interaction that involves ƒÑMƒÒ2(CD11b/CD18) J. Immunol., 160:4057-4066, 1998.
  27. Schraufstatter, I.U., Oades, Z.G., Hoch, R.C., Takamori, H., Burger, M. Importance of the carboxy-terminus of the CXCR2 for signal transduction. Biochem. Biophys. Res. Commun. 24:243-248, 1998.
  28. Norgauer, J., Metzner, B., Czech, W., Schraufstatter, I.U. Reconstitution of chemokine-induced actin polymerization in undifferentiated human leukemia cells (HL60) by heterologous expression of interleukin-8 receptors. Inflamm. Res., 45:127-131, 1996.
  29. Norgauer, J., Metzner, B., Schraufstatter, I.U. Expression and growth-promoting function of the interleukin-8 receptor B in human melanoma cells. J. Immunol., 156:1132-1137, 1996.
  30. Schraufstatter, I.U., Ma, M., Oades, Z.G., Barritt, D.S., Cochrane, C.G. The role of tyr13, ser14, lys15 of IL-8 in the high affinity interaction with the A receptor. J. Biol. Chem., 270:10428-10431, 1995.
  31. Norgauer, J., Krutmann, J., Dobos, G., Traynor-Kaplan, A., Oades, Z., and Schraufstatter, I.U. Actin polymerization, calcium transients, and phospholipid metabolism in human neutrophils after stimulation with interleukin-8 and N-formyl peptide. J. Invest. Dermatol. 102:310-314, 1994.
  32. Schraufstatter, I.U., Barritt, D.S., Ma, M., Oades, Z., Cochrane, C.G. Multiple sites on IL-8 responsible for binding to alpha and beta-IL-8 receptors. J. Immunol. 151:6418-6428, 1993.
  33. Schraufstatter, I.U., Browne, K., Harris, A., Hyslop, P.A., Jackson, J.H., Quehenberger, O., Cochrane, C.G. Mechanisms of hypochlorite (HOCl) injury to target cells. J. Clin. Invest. 85:554-562, 1990.
  34. Schraufstatter, I.U., Hyslop, P.A., Jackson, J., Cochrane, C.G. Oxidant induced DNA damage of target cells. J. Clin. Invest. 84:1040-1048, 1988.
  35. Schraufstatter, I.U., Hinshaw, D.B., Hyslop, D.B., Spragg, R.G., Cochrane, C.G. Oxidant injury of cells: DNA strand breaks activate poly-ADP-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J. Clin. Invest., 77:1312-1320, 1986.
  36. Schraufstatter, I.U., Hyslop, P.A., Hinshaw, D.B., Spragg, R.G., Sklar, L.A., Cochrane, C.G. Oxidant-induced injury of cells and its prevention by inhibitors of poly-ADP-ribose polymerase. Proc. Natl. Acad. Sci., 83:4908-4912, 1986.
  37. Spragg, R.G., Hinshaw, D.B., Hyslop, P.A., Schraufstatter, I.U., Cochrane, C.G. Alterations in adenosine triphosphate and energy charge in cultured andothelial and P388D1 cells following oxidant injury. J. Clin. Invest., 76:1471-1476, 1986.
  38. Schraufstatter, I.U., Hinshaw, D., Hyslop, P., Spragg, R., Cochrane, C.G. Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells. J. Clin. Invest., 76:1131-1139, 1985.
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