Torrey Pines Institute for Molecular Studies science image
Torrey Pines Institute for
Molecular Studies
3550 General Atomics Court, 2-129
San Diego, CA 92121-1122
USA
Scientists
Ingrid Schraufstatter
Adjunct Member
Immunology

858.455.3898 - phone
858.455.3804 - fax

Dr. Schraufstatter earned her M.D. from the University of Aachen in Germany and completed her studies in pharmacology at King's College in London, UK and in immunology at the Scripps Research Institute in La Jolla, CA. She was an Assistant Professor at the Scripps Research Institute in La Jolla, CA from 1989 - 1999 in the Department of Immunology and a Professor from 1999 - 2007 in the Division of Cancer Biology at the La Jolla Institute for Molecular Medicine in San Diego, CA. Dr. Schraufstatter is an Adjunct Member in the Immunology Department at the Torrey Pines Institute for Molecular Studies.

Research Focus

Dr. Schraufstatter's research focuses on the role of chemokines and the anaphylatoxins C3a and C5a on cell signaling and migration of leukocytes, and has over the last several years expanded to the effect of these chemotactic factors on stem cells.

Professional Affiliations

  • Ad hoc reviewer for NIH, TTT and VMD study sections, 1992-4, 2005, 2006.
  • Peer Review Member, Western Review Consortium, American Heart Association, 2006 - present.
  • Juror, AHA Young Investigator award, Western States, 2007.
  • Associate Editor: American Journal of Physiology, Lung Cell Molecular Physiology.
  • Reviewer for: Journal of Biological Chemistry, Journal of Immunology, Journal of Clinical Investigation, (please write out) Cancer Res., Blood, and others.

Publications

  1. DiScipio R.G. and Schraufstatter I.U. The role of the complement anaphylatoxins in the recruitment of Eosinophils. Int. Immunopharmacol., 2007, 7:1909-23
  2. Zhao M, Mueller BM, Discipio RG, Schraufstatter I.U. Akt plays an important role in breast cancer cell chemotaxis to CXCL12. Breast Cancer Res Treat. 2007 Aug 9; [Epub ahead of print] PMID: 17687643
  3. Serobyan N., Jagannathan S., Orlovskaya I., Schraufstatter I.U., Skok M., Loring J., and Khaldoyanidi S. The cholinergic system is involved in regulation of the development of the hematopoietic system., Life Sci. 2007, 80:2352-60
  4. Mueller F.J., Serobyan N., Schraufstatter I.U., DiScipio R.G., Loring J.F., Snyder E.Y., and Khaldoyanidi S.K. Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins. Stem Cells, 2006, 24:2367-72
  5. Wimmer A, Khaldoyanidi SK, Judex M, Serobyan N, Discipio RG, Schraufstatter I.U. CCL18/PARC stimulates hematopoiesis in long-term bone-marrow cultures indirectly through its effect on monocytes, Blood. 2006, 108 : 3722-3729 PMID: 16888095
  6. Discipio RG, Schraufstatter I.U., Sikora L, Zuraw BL, Sriramarao P. C5a mediates secretion and activation of matrix metalloproteinase 9 from human eosinophils and neutrophils. Int. Immunopharmacol. 2006, 6 :1109-1118
  7. Zhao M., DiScipio R., Wimmer A., and Schraufstatter I.U., Regulation of CXCR4-mediated nuclear translocation of ERK1/2, Mol. Pharmacol., 2006, 69 : 66-75 PMID: 16210428
  8. Liu-Bryan R., Pay S., Schraufstatter I.U., and Rose D.M., The CXCR1 tail mediates 1-integrin dependent cell migration via MAP kinase signaling, Biochem. Biophys. Res. Commun., 2005, 332 : 117-125
  9. Serobyan N., Schraufstatter I.U., Strongin A., and Khaldoyanidi S. Nicotinic acetylcholine receptor-mediated activation of endothelial cells results in the arrest of hematopoietic progenitor cells on endothelium. Brit. J. Haematol., 2005, 129 : 257-265
  10. Burger M., Hartmann T., Burger J.A., and Schraufstatter I.U., KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway, Oncogene, 2005, 24:2067-2075, 2005
  11. Zhao M., Wimmer A., Trieu K., DiScipio R.G., and Schraufstatter I.U., Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2, J. Biol. Chem., 2004, 279:49259-49267 PMID: 15364949
  12. Schraufstatter I.U., Takamori H., Sikora L., Sriramarao P., and DiScipio R.D., Eosinophils and monocytes produce pulmonary and activation regulated chemokine (PARC/CCL18), which activates cultured monocytes/macrophages, Am. J. Physiol. Lung Cell Mol. Physiol., 286:L494-L501, 2004
  13. Schraufstatter I.U., Trieu K., Rose D., Terkeltaub R.A., and Burger M., IL-8 mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the EGF-receptor, J. Immunol., 171:6714-6722, 2003
  14. Mockenhaupt M., Peters F., Schwenk-Davoine I., Herouy Y., Schraufstatter I.U., Elsner P., and Norgauer J., Evidence of involvement of CXC-chemokines in proliferation of cultivated human melanocytes. Int J. Mol. Med., 12:597-601, 2003
  15. Schraufstatter I.U., Trieu K., Sikora L., Sriramarao P., and DiScipio R.D., Complement C3a and C5a induce different signal transduction cascades in endothelial cells, J. Immunol. 169:2102-2110, 2002 PMID: 12165538
  16. Schraufstatter I.U., Chung J., and Burger M., IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways, Am. J. Physiol. Lung Cell Mol. Physiol., 280:L1094-L1103, 2001
  17. Browning DD, Diehl WC, Hsu MH, Schraufstatter I.U., Ye RD. Autocrine regulation of interleukin-8 production in human monocytes. Am J Physiol Lung Cell Mol Physiol. 2000, 279(6):L1129-36
  18. Takamori H., Oades Z.G., Burger M., and Schraufstatter I.U., Autocrine growth effect of IL-8 and gro-? on a human pancreatic cancer cell line, CAPAN 1, Pancreas, 21:52-56, 2000
  19. Burger M., Burger J.A., Hoch R.C., Oades Z., Takamori H., and Schraufstatter I.U., Point mutation causing constitutive signaling of the CXCR2 leads to transforming activity similar to KSRV-GPCR, J. Immunol., 163:2017-2022, 1999
  20. Metzner B., Hofmann C., Heinemann C., Zimpfer U., Schraufstatter I.U., Schopf E., and Norgauer J., Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431, Oncol. Rep., 6 : 1405-1410, 1999
  21. Schraufstatter I.U., Oades Z.G., Hoch R.C., Takamori H., and Burger M., Importance of the carboxy-terminus of the CXCR2 for signal transduction, Biochem. Biophys. Res. Commun. 24 : 243-248, 1998
  22. Cochrane CG, Revak SD, Merritt TA, Schraufstatter I.U., Hoch RC, Henderson C, Andersson S, Takamori H, Oades ZG. Bronchoalveolar lavage with KL4-surfactant in models of meconium aspiration syndrome. Pediatr Res. 1998 Nov;44:705-15
  23. DiScipio R.G., Daffern P., Schraufstatter I.U. and Sriramarao P., Human polymorphonuclear leukocytes adhere to complement factor H through an interaction that involves ?M?2(CD11b/CD18), J. Immunol., 160:4057-4066, 1998
  24. Norgauer J., Metzner B., Czech W., and Schraufstatter I.U. Reconstitution of chemokine-induced actin polymerization in undifferentiated human leukemia cells (HL60) by heterologous expression of interleukin-8 receptors. Inflamm. Res., 45:127-131, 1996
  25. Norgauer J., Metzner B., and Schraufstatter I.U. Expression and growth-promoting function of the interleukin-8 receptor B in human melanoma cells, J. Immunol., 156:1132-1137, 1996
  26. Schraufstatter I.U., Ma M., Oades Z.G., Barritt D.S., and Cochrane C.G., The role of tyr13, ser14, lys15 of IL-8 in the high affinity interaction with the A receptor. J. Biol. Chem., 270:10428-10431, 1995
  27. Norgauer J., Krutmann J., Dobos G., Traynor-Kaplan A., Oades Z., and Schraufstatter I.U., Actin polymerization, calcium transients, and phospholipid metabolism in human neutrophils after stimulation with interleukin-8 and N-formyl peptide. J. Invest. Dermatol. 102:310-314, 1994
  28. Schraufstatter I.U., Barritt D.S., Ma M., Oades Z., and Cochrane C.G., Multiple sites on IL-8 responsible for binding to alpha and beta-IL-8 receptors. J. Immunol. 151:6418-6428, 1993
  29. Schraufstatter I.U., Browne K., Harris A., Hyslop P.A., Jackson J.H., Quehenberger O., and Cochrane C.G., Mechanisms of hypochlorite (HOCl) injury to target cells. J. Clin. Invest. 85 : 554-562, 1990
  30. Schraufstatter I.U., Hyslop P.A., Jackson J., and Cochrane C.G., Oxidant induced DNA damage of target cells. J. Clin. Invest. 84:1040-1048, 1988
  31. Schraufstatter I.U., Hyslop P.A., Hinshaw D.B., Spragg R.G., Sklar L.A., and Cochrane C.G., Oxidant-induced injury of cells and its prevention by inhibitors of poly-ADP-ribose polymerase. Proc. Natl. Acad. Sci., 83:4908-4912, 1986
  32. Spragg R.G., Hinshaw D.B., Hyslop P.A., Schraufstatter I.U., and Cochrane C.G., Alterations in adenosine triphosphate and energy charge in cultured andothelial and P388D1 cells following oxidant injury. J. Clin. Invest., 76:1471-1476, 1986
  33. Schraufstatter I.U., Hinshaw D.B., Hyslop D.B., Spragg R.G., and Cochrane C.G., Oxidant injury of cells: DNA strand breaks activate poly-ADP-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J. Clin. Invest., 77:1312-1320, 1986
  34. Schraufstatter I.U., Hinshaw D.., Hyslop P., Spragg R., and Cochrane C.G., Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells., J. Clin. Invest., 76:1131-1139, 1985
  35. Schraufstatter I.U., Hinshaw D.., Hyslop P., Spragg R., and Cochrane C.G., Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells., J. Clin. Invest., 76:1131-1139, 1985
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