Torrey Pines Institute for Molecular Studies science image
Torrey Pines Institute for
Molecular Studies
5775 N. Old Dixie Highway
Fort Pierce, FL 34946-7302
USA
Scientists
Jose Luis Medina-Franco
Assistant Member
Computer Aided Drug Design

772.462.0891 - phone
772.462.0886 - fax

Dr. Jose Luis Medina-Franco received a Bachelor of Science in chemistry from the National Autonomous University of Mexico (UNAM) in 1998 and that same year, he joined Procter & Gamble in Mexico City, working in the research and development department. He received a Masters in Science in 2002 ("Synthesis of pyridinone-2(1H)-ones as precursors of potential HIV-1 Reverse Transcriptase Inhibitors") and a Ph.D. degree in 2005 ("Computer-Aided Drug Design. HIV-1 Reverse Transcriptase Inhibitors, Hypocholesterolemic and Antiparasitic Compounds"), both in Chemisty from UNAM, working in the laboratory of Professor Rafael Castillo. During his doctoral studies, Dr. Medina-Franco participated in research visits with Professor Jesus Jimenez-Barbero, in Madrid, Spain; Professor Alexander Tropsha at the University of North Carolina at Chapel Hill and Professor Gerald M. Maggiora at the University of Arizona. In 2005, he joined Professor Maggiora as a postdoctoral fellow. In August 2007, Dr. Medina-Franco was named Assistant Member at the Torrey Pines Institute for Molecular Studies in Florida.

Research Focus

Computer-aided drug design.

Honors and Awards

  • Antonio Caso Medal, National Autonomous University of Mexico. Top grade average of Postgraduate studies in Chemistry, 2005.
  • Gabino Barreda Medal, National Autonomous University of Mexico. Top grade average of the B.S. in Chemistry, 2000.
  • Accelrys Fellowship at the Fifth European Workshop in Drug Design. Siena, Italy, 2005.
  • Science and Technology National Council Fellowship at the University of Arizona, 2005.
  • Science and Technology National Council Fellowship at the National Autonomous University of Mexico, M.Sc. and Ph.D. studies, 2000-2005.
  • National Autonomous University of Mexico Fellowship at the National Autonomous University of Mexico, M.Sc. and Ph.D. studies, 2000-2005.
  • Drew University Fellowship at the 2002 Residential School on Medicinal Chemistry, New Jersey, 2002.
  • QFB Santiago Maza Award, XXXIV Pharmaceutical Sciences National Meeting, Manzanillo, Mexico, 2001.
  • Recognition Shares. Procter & Gamble, Global Home Care - Belgium, 1999.
  • National Autonomous University of Mexico Foundation Fellowship at the University of Texas at Austin, 1997.
  • Austromex Award, B.S., 1997.
  • National Autonomous University of Mexico Foundation Fellowship at the National Autonomous University of Mexico, B.S. studies, 1993-1996.

Professional Activities

  • Member of the American Chemical Society, since 2004.
  • Reviewer for: Journal of Computer-Aided Molecular Design, European Journal of Pharmaceutical Sciences, Chemical Biology and Drug Design, European Journal of Medicinal Chemistry, ChemMedChem, Journal of the Mexican Chemical Society.
  • Organizer of symposium, Rational Drug Design at XXXIX National Meeting of the Mexican Chemical Society. Merida, Mexico, October 3-7, 2004.
  • Member of the National Researcher System, National Council of Science and Technology, Mexico, 2007.

Publications

  1. Medina-Franco, J. L.; Martínez-Mayorga, K.; Juárez-Gordiano, C.; Castillo R. "Pyridin-2(1H)-ones: A promising class of HIV-1 non-nucleoside reverse transcriptase inhibitors. ChemMedChem 2007, 2, 1141-1147.
  2. Scior, J. T.; Bernard, P.; Medina-Franco, J. L.; Maggiora, G. M. "Large Compound Databases for Structure-Activity Relationships Studies in Drug Discovery." Mini-Rev. Med. Chem. 2007, 7, 851-860.
  3. López-Vallejo, F.; Medina-Franco, J. L.; Rodríguez-Morales, S.; Hernández-Campos, A.; Hernández-Luis, F.; Yépez-Mulia, L.; Castillo, R. "Molecular Modeling of Some 1H-Benzimidazole Derivatives with Antiamoebic Activity: A Comparative Molecular Field Analysis Study." Bioorg. Med. Chem. 2007, 15, 1117-1126.
  4. Medina-Franco, J. L. "Aplicaciones Exitosas del Diseño de Fármacos Utilizando Métodos Computacionales (Successful Applications of Computer-Aided Drug Design)." Ciencia (Mexico). 2007, AMC, http://revistaciencia.amc.edu.mx/index.php?option=com_content&task=view&id=79&Itemid=43.
  5. Medina-Franco, J. L.; Petit, J.; Maggiora, G. M. "Hierarchical Strategy for Identifying Active Chemotype Classes in Compound Databases." Chem. Biol. Drug. Des. 2006, 67, 395-408.
  6. Medina-Franco, J. L.; López-Vallejo, F.; Castillo R. "Diseño de Fármacos Asistido por Computadora (Computer-Aided Drug Design)." Educ. Quim. 2006, 17, 114-120.
  7. Medina-Franco, J. L.; Golbraikh, A.; Oloff, S.; Castillo, R.; Tropsha, A. "Quantitative Structure-Activity Relationship Analysis of Pyridinone HIV-1 Reverse Transcriptase Inhibitors Using the k Nearest Neighbor Method and QSAR-Based Database Mining." J. Comput.-Aided. Mol. Des. 2005, 19, 229-242.
  8. Medina-Franco, J. L.; López-Vallejo, F.; Rodríguez-Morales, S.; Castillo, R.; Chamorro, G.; and Tamariz, J. "Molecular Docking of the Highly Hypolipidemic Agent -Asarone with the Catalytic Portion of HMG-CoA Reductase." Bioorg. Med. Chem. Lett. 2005, 15, 989-994.
  9. Medina-Franco, J. L.; Juárez-Gordiano, C.; Hernández-Campos, A; Duarte, G.; Guzmán, M.; Castillo, R. "New Fragmentation Process of Pyridin-2(1H)-ones upon Electron Impact Ionization." Rapid Commun. Mass Spectrom. 2005, 19, 2350-2354.
  10. Soria-Arteche, O.; Castillo, R.; Hernández-Campos, A.; Hurtado-de la Peña, M.; Navarrete-Vázquez, G.; Medina-Franco, J. L.; Gómez-Flores, K. "Studies on the Selective S-Oxidation of Albendazole, Fenbendazole, Triclabendazole, and other Benzimidazole sulfides." J. Mex. Chem. 2005, 49, 349-354.
  11. Medina-Franco, J. L.; Rodríguez-Morales, S.; Juárez-Gordiano C.; Hernández-Campos, A.; Castillo, R. "A Docking Based CoMFA Study of Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1 of the Pyridinone Derivative Type." J. Comput.-Aided. Mol. Des. 2004, 18, 345-360.
  12. Medina-Franco, J. L.; Rodríguez-Morales S.; Juárez-Gordiano, C.; Hernández-Campos A.; Jiménez-Barbero, J.; Castillo, R. "Flexible Docking of Pyridinone Derivatives into de Non-nucleoside Binding Site of HIV-1 Reverse Transcriptase." Bioorg. Med. Chem. 2004, 12, 6085-6095.
  13. Martínez-Mayorga, K.; Medina-Franco, J. L.; Mari, S.; Cañada, F. Javier; Rodríguez-García E.; Vogel, P.; Li, H.; Blériot, Y.; Sinaÿ, P.; Jiménez-Barbero, J. "The Conformational Behavior of Novel Glycosidase Inhibitors with Substituted Azepan Structures. A NMR and Modeling Study." Eur. J. Org. Chem. 2004, 10, 4119-4129.

    14. In Press

  14. Medina-Franco, J. L.; Maggiora, G. M.; Giulianotti, M. A.; Pinilla, C.; Houghten, R. A. "A Similarity-based data-fusion approach to the visual characterization and comparison of compound databases." Chem. Biol. Drug. Des. 2007.
  15. Houghten, R. A.; Pinilla, C.; Appel, J. R.; Giulianotti, M. A.; Nefzi, A.; Ostresh, J. M.; Dooley, C. T.; Maggiora, G. M.; Medina Franco, J. L.; Brunner, D.; Schneider, J. "Mixture-based Synthetic Combinatorial Libraries: Direct in vivo Testing, Scaffold Ranking, and Enhanced Deconvolution Using Computational Approaches." J. Comb. Chem.

Presentations

  1. Medina-Franco, J. L.; Maggiora, G. M.; Giulianotti, M. A.; Pinilla, C.; Houghten, R. A.; Welsh, K.; Reed, J. C. Novel Representation of Synthetic Combinatorial Libraries Using Cheminformatic and Rule-Based Methods. VI International Symposium: "Chemical Research in the Border Region", Tijuana, B. C., November 15-17, 2006.
  2. Medina-Franco, J. L.; Petit, J.; Maggiora, G. M. Hierarchical Strategy for Identifying Active Chemotype Classes in Compound Databases. The 19th Rocky Mountain Regional Meeting of the American Chemical Society, Tucson, AZ, October 14-18, 2006.
  3. Medina-Franco, J. L.; Scior, J. T. Tools for Teaching Structure-based Drug Design. The 19th Rocky Mountain Regional Meeting of the American Chemical Society, Tucson, AZ, October 14-18, 2006.
  4. Medina-Franco, J. L.; Petit, J.; Maggiora, G. M. Chemotype−based Hierarchical Classification and Rough Set Theory Analysis of the NCI AIDS Database. 232nd American Chemical Society Meeting, San Francisco, CA, September 10-14, 2006.
  5. Medina-Franco, J. L.; Maggiora, G. M.; Goodwin, J. T.; Burton, P. S. Rule-based Analysis of ADMET Data Using Rough Set Theory. 232nd American Chemical Society Meeting, San Francisco, CA, September 10-14, 2006.
  6. López-Vallejo, F.; Medina-Franco, J. L.; Rodríguez-Morales, S.; Hernández-Campos, A.; Hernández-Luis, F.; Yépez-Mulia, L.; Castillo, R. Molecular Modeling of Some 1H-Benzimidazole Derivatives with Antiamoebic Activity: A Comparative Molecular Field Analysis Study. 232nd American Chemical Society Meeting, San Francisco, CA, September 10-14, 2006.
  7. Hernández-Campos, A.; Medina-Franco, J. L.; Yépez-Mulia, L.; López-Balbiaux, N.; Hernández-Luis, F. Castillo, R. Design, Synthesis and QSAR-based Activity Prediction of Novel Benzimidazole Derivatives Against G. intestinalis. 11th International Congress of Parasitology, Glasgow, Scotland, August 6-11, 2006.
  8. Medina-Franco, J. L.; Petit, J.; Castillo, R.; Maggiora, G. M. Structure-Activity Relationships with Rough Set Theory. 2005 AHSC Frontiers in Biomedical Research Poster Forum, Tucson, AZ, October 28, 2005.
  9. Medina-Franco, J. L.; Petit, J.; Castillo, R.; Maggiora, G. M. Structure Activity Relationships with Rough Set Theory. Fifth European Workshop in Drug Design. Siena, Italy, May 29-June 5, 2005.
  10. Medina-Franco, J. L.; Golbraikh, A.; Castillo, R.; Tropsha, A. Quantitative Structure-Activity Relationship Analysis of Pyridinone HIV-1 Reverse Transcriptase Inhibitors Using the k Nearest Neighbor Method and QSAR-Based Database Mining. 229th American Chemical Society Meeting, San Diego, CA, March 13-17, 2005.
  11. Medina-Franco, J. L.; López-Vallejo, F.; Rodríguez-Morales, S.; Castillo, R.; Chamorro, G.; Tamariz, J. Molecular Docking of the Highly Hypolipidemic Agent α-Asarone with the Catalytic Portion of HMG-CoA Reductase. 229th American Chemical Society Meeting, San Diego, CA, March 13-17, 2005.
  12. Medina-Franco, J. L.; López-Vallejo, F.; Rodríguez-Morales, S.; Hernández-Campos, A.; Hernández-Luis, F.; Yépez-Mulia, L.; Oloff, S.; Shen, M.; Tropsha, A.; Castillo, R. kNN-QSAR Study of Bencimidazol and Benzoxazol Derivatives Identify new Compounds Active Against Giardia intestinalis. XVI Parasitology National Meeting. La Trinidad, Mexico, October 21-25, 2004.
  13. López-Vallejo, F.; Medina-Franco, J. L.; Rodríguez-Morales, S.; Hernández-Campos, A.; Hernández-Luis, F.; Yépez-Mulia, L.; Tropsha, A.; Shen, M.; Oloff, S.; Castillo, R. Development of kNN and 3D-QSAR Models for Rational Design of Compounds with Activity Against Entamoeba histolytica and Application of kNN-QSAR Models to Database Mining. The 2nd Brazilian Symposium on Medicinal Chemistry. Rio de Janeiro, Brazil, November 22-25, 2004.
  14. Medina-Franco, J. L.; Golbraikh, A.; Oloff, S.; Tropsha, A.; Hernández-Campos, A. Castillo, R. kNN-QSAR Study of HIV-1 Reverse Transcriptase Inhibitors and Data Base Mining. XXXVII Pharmaceutical Sciences National Meeting. Acapulco, Mexico, October 21-25, 2004.
  15. Medina-Franco, J. L.; Rodríguez-Morales, S.; López-Vallejo, F.; Hernández-Campos, A.; Jiménez-Barbero, J.; Castillo, R. Computer Aided Drug Design: Applications to the Design of HIV-1 Reverse Transcriptase Inhibitors. XXXVII Pharmaceutical Sciences National Meeting. Acapulco, Mexico, October 21-25, 2004.
  16. López-Vallejo, F.; Medina-Franco, J. L.; Rodríguez-Morales, S.; Hernández-Campos, A.; Hernández-Luis, F.; Yépez-Mulia, L.; Castillo, R. Development of 2D and 3D QSAR Predictive Models to the Design of Compounds Active Against Entamoeba histolytica. XXXVII Pharmaceutical Sciences National Meeting. Acapulco, Mexico, October 21-25, 2004.
  17. Juárez-Gordiano, C.; Medina-Franco, J. L.; Hernández-Campos, A.; Castillo, R.; Reyes Chilpa, R. Design and Synthesis of 2-Pyridinones as Putative Antiviral Drugs. XXXIX National Meeting of the Mexican Chemical Society. Merida, Mexico, October 3-7, 2004.
  18. Medina-Franco, J. L.; Rodríguez-Morales, S.; Juárez-Gordiano, C.; Hernández-Campos, A.; Castillo, R. Docking, CoMFA and CoMSIA Studies of HIV-1 Reverse Transcriptase Inhibitors of the Pyridinone Derivative Type. 228th American Chemical Society Meeting, Philadelphia, PA, August 22-26, 2004.
  19. Medina-Franco, J. L.; Rodríguez-Morales, S.; Juárez-Gordiano, C.; Hernández-Campos, A.; Jiménez-Barbero, J.; Castillo, R. Ligand-based Design of Pyridinone Derivatives with Potential Activity Against Mutant Strains of HIV-1 Reverse Transcriptase. 228th American Chemical Society Meeting, Philadelphia, PA, August 22-26, 2004.
  20. Martínez-Mayorga, K.; Medina-Franco, J. L.; Cañada, F. Javier; Blériot, Y.; Sinaÿ, P.; Jiménez-Barbero, J. Conformational Study of Monosaccharide Analogues with 1H-NMR, NOE Experiments and Molecular Dynamics. 228th American Chemical Society Meeting, Philadelphia, PA, August 22-26, 2004.
  21. Reyes-Trejo, L. J.; Medina-Franco, J. L.; Rodriguez-Morales, S.; Castillo, R.; Melchor-Macias, P.; Trujillo-Ferrara, J. Quantum Mechanical and Docking Studies of Acetylcholinesterase Inhibitors of the N-arylmaleimide type. 228th American Chemical Society Meeting, Philadelphia, PA, August 22-26, 2004.
  22. Medina-Franco, J. L.; Rodríguez-Morales, S.; Juárez-Gordiano C.; Hernández-Campos, A.; Castillo, R. A three-dimensional Quantitative Structure-Activity Relationship Study of Pyridin-2(1H)-one Analogues as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2003 American Association of Pharmaceutical Sciences, Annual Meeting and Exposition, Salt Lake City, Utah, October 26-30, 2003.
  23. Martínez-Mayorga, K.; Medina-Franco, J. L.; Cañada, F. J.; Blériot, Y.; Sinaÿ, P.; Jiménez-Barbero, J. Conformational Study of Monosaccharide Analogues with NMR and Molecular Modeling. Small Molecule NMR Conference, Verona, Italy, September 14-17, 2003.
  24. Medina-Franco, J. L.; Rodríguez-Morales, S.; Juárez-Gordiano, C.; Hernández-Campos, A.; Jiménez-Barbero, J.; Castillo, R. Flexible Docking of Pyridinone Derivatives into Their Putative Binding Pocket of HIV-1 Reverse Transcriptase. XIII Meeting of the Medicinal Chemistry Society of Spain, Santiago de Compostela, Spain, September 9-12, 2003.
  25. Medina-Franco, J. L.; Hernández-Campos, A.; Castillo, R. Electronic Notebook. XXV Latino-American Chemistry Meeting, Cancun, Mexico, September 22-26, 2002.
    26. Medina-Franco, J. L.; Juárez-Gordiano C.; Duarte, G.; Gutierrez, M. Hernández-Campos, A.; Castillo, R. Mass Spectrometry of 5,6-dialquil-disustituted Pyridin-2(1H)-ones. XXV Latino-American Chemistry Meeting, Cancun, Mexico, September 22-26, 2002.

Invited Talks

  • Molecular Modeling and Cheminformatics Applied to Drug Design, Tijuana Technological Institute, Tijuana, BC, Mexico, May 4, 2007.
  • Computational Approaches to Characterize Structure-Activity Relationships in Compound Databases, University of Arizona, Tucson, AZ, February 1, 2007.
  • Computational Tools in Drug Design, University of Guanajuato, Mexico, November 25, 2004.
  • Molecular Docking and Computer-Aided Drug Design, XXXIX National Meeting of the Mexican Chemical Society, Merida, Mexico, October 6, 2004.
  • Computational Tools in the Computer-Aided Drug Design, National Autonomous University of Mexico, Mexico City, July 2, 2004.
  • Fighting Diseases with Chemistry, Sciences and Humanities High School, Mexico City, May 25, 2004.
  • Computer-Aided Drug Design, National Autonomous University of Mexico, Graduate Division of the School of Chemistry, Mexico City, February 13, 2004.

Attended Courses

  • National Biomedical Computation Resource Summer Institute, University of California, San Diego / The Scripps Research Institute, August 7-11, 2006.
  • Biocomputing @ UNM, University of New Mexico, April 17, 2006.
  • Fifth European Workshop in Drug Design, Siena, Italy, May 29 - June 5, 2005.
  • In Silico Drug Discovery, MolSoft, La Jolla, California, November 15 - 16, 2002.
  • Residential School on Medicinal Chemistry, Drew University, New Jersey, June 9 - 14, 2002.
  • Pharmacy Compounding Seminar, Houston, Texas, August, 1997.
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