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CALIFORNIA SCIENTISTS James Binley Todd Braciak Yang D. Dai Joanna Davies Brigitte Dudouet Richard A. Houghten Tony Hugli Valeria Judkowski J. Patrick Kampf Sophia Khaldoyanidi Alan Kleinfeld Prasad Koka Vipin Kumar Eugene G. Levin David Loskutoff Adel Nefzi Ron Ogata Clemencia Pinilla Claudia Raja Gabaglia Roy Riblet Fahu Samad Sally Sarawar Eli Sercarz Ingrid Schraufstatter Darcy Wilson FLORIDA SCIENTISTS Christopher Armishaw Colette Dooley Marc Giulianotti Richard A. Houghten Jose Luis Medina-Franco Karina Martinez Mayorga

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Marc Giulianotti earned his Bachelor of Science in Chemistry and Biochemistry from the University of California, San Diego in 1995 and his Masters in Business Administration from San Diego State University in 2001. Marc joined the Torrey Pines Institute as a Research Associate in 1995 and his research focused on design of novel combinatorial libraries. He held this position until 2001 and then became the Business Development Manager for Mixture Sciences, Inc., a Torrey Pines spin-off company. Marc was tapped as Directory of Chemistry Operations for the Torrey Pines Institute's Florida base in June 2007.

Research Focus

Marc Giulianotti directs a team of scientists that develops novel chemistry methods, including combinatorial and computation chemistry, for rapidly identifying lead compounds and clinical candidates for a variety of indications such as pain management, cancer, central nervous system disorders, and HIV/AIDS.

Publications

1. Nefzi, A.; Giulianotti, M. A.; Houghten, R. A. Solid Phase Synthesis of 2,4,5-Trisubstituted Thiomorpholine-3-ones. Tetrahedron Letters. 1998, 39, 3671-3674.
2. Nefzi, A.; Ostresh, J. M.; Giulianotti, M. A.; Houghten, R. A. Efficient Solid Phase Synthesis of 3,5-Disubstituted Hydantoins. Tetrahedron Letters. 1998, 39, 8199-8202.
3. Nefzi, A.; Ong, N. A.; Giulianotti, M. A.; Houghten, R. A. Solid-Phase Synthesis of 1,4-Benzothiazepin-5-one Derivatives. Tetrahedron Letters. 1999, 40, 4939-4942.
4. Nefzi, A.; Ostresh, J. M.; Giulianotti, M. A.; Houghten, R. A. Solid-Phase Synthesis of Trisubstituted 2-imidazolidones and 2-imidazoldinethiones. J. Com. Chem. 1999, 1, 195-198.
5. Nefzi, A.; Giulianotti, M. A.; Houghten, R. A. Solid-phase synthesis of 1,6-disubstituted-2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids. Tetrahedron Letters. 1999, 40, 8539-8542.
6. Nefzi, A.; Giulianotti, M. A.; Houghten, R. A. Solid-phase synthesis of substituted 2,3-Diketopiperazines from Reduced Polyamides. Tetrahedron. 2000, 56, 3319-3326.
7. Nefzi, A.; Giulianotti, M. A.; Houghten, R. A. Solid-phase synthesis of branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones. Tetrahedron Letters. 2000, 41, 2283-2287.
8. Nefzi A., Giulianotti, M. A.; Houghten, R. A. Solid-phase synthesis of bis-heterocyclic compounds from resin-bound orthogonally protected lysine. 2001 J. Comb. Chem. 3, 68-70.
9. Nefzi, A., Giulianotti, M. A., Truong, L., Rattan, S., Ostresh, J. M., Houghten, R. A. Solid phase synthesis of linear ureas tethered to hydantoins and thiohydantoins. 2002 J. Comb. Chem. 4:175-178.
10. Giulianotti, M. A., Nefzi, A. Efficient approach for the diversity-oriented synthesis of macro-heterocycles on solid-support. 2003 Tetrahedron Letters 44: 5307-5309.
11. Sospedra, M., Muraro, P., Stefanova, I., Zhao, Y., Chung, K., Li, Y., Giulianotti, M. A., Simon, R., Mariuzza, R., Pinilla, C., Martin, R. Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype. 2006 J. Immunol. 36:1951-1961.