Torrey Pines Institute for Molecular Studies science image
Torrey Pines Institute for
Molecular Studies
3550 General Atomics Court, 2-129
San Diego, CA 92121-1122
USA
Scientists
Sophia Khaldoyanidi
Associate Member

858.597.3879 - phone
858.597.3804 - fax
contact by email

Dr. Khaldoyanidi received her M.D. from the Medical State University in Novosibirsk, Russian Federation in 1989 and her Ph.D. in Immunology/Hematology from the Institute of Clinical Immunology, also in Novosibirsk in 1993. She was a guest scientist at the Heidelberg German Cancer Research Center and the Institute for Genetics within the Karlsruhe Research Center, both in Germany. From 1998 - 1999, she was a postdoctoral fellow at the Medical Biology Institute in La Jolla, CA and then she joined the Department of Vascular Biology at the La Jolla Insitute for Molecular Medicine (LJIMM) as a staff scientist. In 2001, Dr. Khaldoyanidi was promoted to the Assistant Professor position at LJIMM. In 2005, she was tapped as director of the Stem Cells and Regenerative Medicine Program at LJIMM and she took a sabbatical with the Stem Cell Center at the Burnham Institute for Medical Research. Dr. Khaldoyanidi joined the Torrey Pines Institute for Molecular Studies as an Associate Member in 2007.

Research Focus

The laboratory of Dr. Khaldoyanidi is focused on the basic biology of stem cells and on their use for tissue regeneration. The current projects include studies on somatic multipotent stem cells, such as hematopoietic stem cell (HSC), mesenchymal stem cells (MSCs) and neural stem cells (NSCs), as well as on pluripotent stem cells (ESC).

The fate of stem cells depends on their interactions with the local microenvironment, i.e. the niche. Therefore, one of the aspects of Dr. Khaldoyanidi's research is to identify cells that contribute to the complex structure of the hematopoietic niche in bone marrow. In addition, the non-cellular compartment of the niche, including extracellular matrix molecules, chemokines, anaphylotoxins and cholinergic mediators is of interest. Ongoing studies are designed to investigate the molecular mechanisms that mediate the effect of these factors on the fate of stem cells and on the cross-talk between stem cell and the niche. We are also interested in understanding the mechanisms regulating differentiation of embryonic stem cells (ESC).

Transplantation of stem cells is a required procedure for treatment of many pathological conditions. When administered systemically, the efficiency of transplantation depends on the homing ability of stem cells. Dr. Khaldoyanidi's laboratory established a new in vitro method, based on the 3-dimesional (3D) flow chamber device, to investigate the effects of the organ-specific microenvironment on stem cell - endothelial cell interactions under physiological shear stress conditions, including rolling, adhesion, and transmigration across an endothelial layer. This approach can provide a basis for better understanding of the mechanisms regulating stem cell migration.

Honors and Awards

  • Medical State University, Novosibirsk, Stipend of Excellence, 1983-1989.
  • Boehrihger Ingelheim, Germany, Guest Scientist Award, 1993.
  • German Cancer Research Center, Heidelberg, Germany, Guest Scientist Award, 1994-1995.
  • Forschungszentrum Karlsruhe, Germany, Guest Scientist Award, 1995-1998.
  • American Society of Hematology, travel award, 1999.
  • International Society of Hematology, travel award, 2003.
  • International Drug Discovery Science and Technology, Honorary Member, 2004.
  • International Society of Hematology, Member of the Month, October 2006.
  • New Investigator Award 10KT-0036 from TRDRP, 06/01/2001-05/3/2004.
  • Idea Award 11IT-0020 from TRDRP, 07/01/2002-12/31/2003.
  • Exploratory Award R21DK067084 from NIH/NIDDK, 04/01/2004 - 03/31/2007.
  • Career development award K18 HL081089-01 from NIH/NIDDK, 04/01/2005-06/31/2007.
  • Research grant award from TRDRP 16RT-0134 , 07/01/2007-06/31/2010.
  • Small technology transfer research award from R41CA126004 from NIH, 12/01/2007-11/30/2008

Professional Affiliations

  • American Society of Hematology
  • International Society of Experimental Hematology
  • International Society for Hyaluronan Science
  • Reviewer for Stem Cells, British Journal of Haematology, International Journal of Biochemistry and Cell Biology, International Journal of Biological Macromolecules, Journal of Immunological Methods.
  • Grant reviewer for Universite du Luxembourg, 2006; PhM Research Management Group, 2007; NIH, 2008.
  • Collaborative Project with Hollis-Eden Pharmaceuticals, 2004.
  • Co-founder and Chief Scientific Officer, Cascade LifeSciences Inc., 2004.
  • Member of the Scientific Advisory Board, America Stem Cell Bank, 2005.
  • Member of the Scientific Advisory Board, Cascade LifeSciences Inc., 2007.

Invited Seminars

  • Medical Biology Institute, La Jolla, California, 1997.
  • University California San Diego, La Jolla, California, 1997.
  • ViaCell Incorporation, Boston, MA, 2002.
  • Institute for Genetics, Karlsruhe Research Center, Karlsruhe, Germany, 2002.
  • Southern California Stem Cell Consortium, Burnham Institute, La Jolla, CA, 2003.
  • Institute for Genetics, Karlsruhe Research Center, Karlsruhe, Germany, 2004.
  • Chemicon International, a division of Serological Corporation, Temecula, CA, 2004.
  • Noble lecture tour with Dr. Gunter Blobel, Nobel Price Laureate, Beijing, Dalian, Nanjin and Shanghai, China, 2004.
  • Jawaharlal Nehru University, December, Delhi, India, 2005.
  • Oregon National Primate Research Center, Portland, OR, 2005.
  • NIH, invited seminar, Bethesda, MD, April 25, 2006.
  • HyClone, invited seminar, Logan, UT, May 23, 2006.
  • Institute for Stem Cell Research, Neuherberg, Germany, August 2006.
  • Invitrogen, invited seminar, Carlsbad, CA, February 2007.
  • Torrey Pines Institute for Medical Studies, San Diego, CA, May 2007.

Plenary Sessions

  • 2nd Annual Congress of International Drug Discover Science and Technology, Beijing, China, 2004.
  • TRDRP, annual meeting, Los Angeles, CA, 2005.
  • BIOCOM, plenary session on Stem Cells, San Diego, CA, 2005.
  • WATCH 2005, Delhi, India, 2005.
  • 2nd International Symposium on Non-Neural Acetylcholine, Mainz, Germany, 2006.
  • 35th Annual Meeting of the International Society for Experimental Hematology, ELTF Panel, Minneapolis, Minnesota, 2006.
  • International Conference on Hyaluronan 2007, Charleston, SC, 2007.
  • Stem Cell Symposium, Children's Hospital Orange County, CA, March 2007.

Oral Presentations

  1. CD44 expression by peripheral blood mononuclear cells of patients with Non-Hodgkin lymphomas. 10th Spring Meeting of the German Society for Immunology, Heidelberg, Germany, 1994.
  2. Comparison of hematopoiesis in bone marrow of allergen challenged and IL-5 transgenic mice. American Academy of Allergy, Asthma and Immunology 56th Annual Meeting, San Diego, California, USA, 1999.
  3. Monoclonal antibody to CD44 splice variants enhances hematopoiesis in LTBMC via up-regulation of GM-CSF and IL-6. 13th International Symposium on Molecular Biology of Hematopoiesis and Treatment of Leukemia, Lymphoma & Cancer, New York, USA, 2000.
  4. Recovery of hematopoiesis after irradiation and bone marrow transplantation or after 5FU administration is facilitated by hyaluronan treatment. International Symposium Recent Advances in Stem Cell Transplantation, San Diego, California, 2003.
  5. The effect of nicotine on hematopoietic stem cell homing. International Symposium Recent Advances in Stem Cell Transplantation, San Diego, California, 2003.
  6. Hyaluronan facilitates recovery of ablated hematopoiesis via activation of cytokine production by bone marrow macrophages. 32nd Annual Meeting of the International Society for Experimental Hematology, Paris, France 2003.
  7. Hyaluronic acid regulates hematopoiesis via activation of cytokine production by bone marrow macrophages. International Conference Hyaluronan 2003, The Cleveland Clinic & Learner Research Institute, Cleveland, USA, 2003.
  8. The CD44/HA pathway regulates the hematopoiesis-supportive function of the bone marrow microenvironment. 33rd Annual Scientific meeting of the International Society for Experimental Hematology, New Orleans, 2004.
  9. The role of hyaluronan in recruitment and retention of HSC in the hematopoietic niche. 35th Annual Scientific meeting of the International Society for Experimental Hematology, Minneapolis, 2006.

Publications

  1. Baranovskaya, S, Martin, Y, Alonso, S, Pisarchuk, KL, Falchetti, M, Dai, Y, Khaldoyanidi, S, Krajewski, S, Novikova, I, Sidorenko, YS, Perucho, M, Malkhosyan, SR. Down-regulation of epidermal growth factor receptor by selective expansion of a 5-end regulatory dinucleotide repeat in colon cancer with microsatellite instability. Clin Cancer Res. 15(14):4531-7, 2009.
  2. Schraufstatter, I.U., DiScipio, R.G., Zhao, M., Khaldoyanidi, S.K. C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation. J. Immunol. 182(6):3827-36, 2009.
  3. Khaldoyanidi, S. Directing Stem Cell Homing. Cell Stem Cell, (2):198-200, 2008.
  4. Orlovskaya, I., Schraufstatter, I., Loring, J. and Khaldoyanidi, S. Hematopoietic differentiation of embryonic stem cells. Methods 45:159-167, 2008.
  5. Serobyan, N., Jagannathan, S., Orlovskaya, I., Schraufstatter, I.U., Loring, J., Skok, M. Khaldoyanidi, S.K. The Cholinergic System is involved in Regulation of the Development of the Hematopoietic System. Life Sci. 80(24-25):2352-60, 2007.
  6. Serobyan, N., Jagannathan, S., Orlovskaya, I., Schraufstatter, I.U., Skok, M., Loring, J., Khaldoyanidi, S.K. The cholinergic system is involved in regulation of the development of the hematopoietic system. Life Sci. 80:2352-60, 2007.
  7. Mueller, F.J., Serobyan, N., Schraufstatter, I.U., DiScipio, R.G., Loring, J.F., Snyder, E.Y., Khaldoyanidi, S.K. Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins. Stem Cells, 24:2367-72, 2006.
  8. Wimmer, A., Khaldoyanidi, S.K., Judex, M., Serobyan, N., Discipio, R.G., Schraufstatter, I.U. CCL18/PARC stimulates hematopoiesis in long-term bone-marrow cultures indirectly through its effect on monocytes. Blood. 108:3722-3729, 2006.
  9. Matrosova, V., Orlovskaya, I., Serobyan, N., McClelland, M., Khaldoyanidi, S.K. Hyaluronan facilitates recovery of hematopoiesis after therapy-induced myelosuppression. Hyaluronan, structure, metabolism, biological activities, therapeutic applications. Editors: E. Balazs and V. Hascall. Volume II, pp. 813-820, 2005.
  10. Serobyan, N., Orlovskaya, I., Kozlov, V., Khaldoyanidi, S.K. Exposure To Nicotine During Gestation Interferes With The Colonization Of Fetal Bone Marrow By Hematopoietic Stem /Progenitor Cells. Stem Cell and Development, 14:81-91, 2005.
  11. Serobyan, N., Schraufstatter, I.U., Strongin, A., Khaldoyanidi, S.K. Nicotinic acetylcholine receptor-mediated activation of endothelial cells results in the arrest of hematopoietic progenitor cells on endothelium. Brit. J. Haematol. 129:257-265, 2005.
  12. Matrosova, V., Orlovskaya, I., Serobyan, N., Khaldoyanidi, S.K. Hyaluronic acid facilitates recovery of hematopoiesis impaired by 5-fluouracil administration. Stem Cells, 22:544-555, 2004.
  13. Khaldoyanidi, S.K., Glinsky, V.V., Sikora, L., Glinskii, A.B., Mossine, V.V., Glinsky, G.V., Sriramarao, P. MDA-MB-435 human breast carcinoma cell homo- and heterotypic adhesion under flow conditions is mediated in part by Thomsen-Friedenreich antigen-galectin-3 interactions. JBC, 278(6):4127-34, 2003.
  14. Khaldoyanidi, S.K., Sikora, L., Rothenberg, M., Broide, D., Sriramarao, P. Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen. Blood, 101(3):863-8, 2003.
  15. Khaldoyanidi, S.K., Karakhanova, S., Sleeman, J., Herrlich, P., Ponta, H. CD44 variant specific antibodies trigger hemopoiesis by selective release of cytokines from bone marrow macrophages. Blood, 99(11):3955-3961, 2002.
  16. Khaldoyanidi, S.K., Sikora, L., Orlovskaya, I., Matrosova, V., Kozlov, V., Sriramarao, P. Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal cells. Blood, 98(2):303-312, 2001.
  17. Chernukhin, I.V., Khaldoyanidi, S.K., Orlovskaya, I.A., Matrosova, V.Y., Svinarchuk, F.P., Konevetz, D.A., Vlasov, V.V., Gaidul, K.V., Kozlov, V.A. A role of endogenous retroviral MCF env Gene in proliferation of pluripotent hemopoietic progenitors in mice. Russ.J.Immunol. 5(1):19-26, 2000.
  18. Muller-Sieburg, C., Deryugina, E., Khaldoyanidi, S., O’Rourke, A. Tissue- and epitope-specific mechanisms account for the diverse effect of anti-CD44 antibodies on the maintenance of primitive hematopoietic progenitors in vitro. BCMD, 26, 291-302, 2000.
  19. Khaldoyanidi, S.K., Moll, J., Karakhanova S.S., Herrlich, P., Ponta, H. Hyaluronate-enhanced hematopoiesis: Tow different receptors trigger the release of interleukin-1beta and interleukin-6 from bone marrow macrophages. Blood, 94(3), 940-949, 1999.
  20. Roesel, M., Khaldoyanidi, S.K., Zawadzki, V., Zoeller, M. Involvement of CD44 variant isoform v10 in progenitor cell adhesion and maturation. Experimental Hematology, 27, 698-711, 1999.
  21. Tuzova, M.N., Khaldoyanidi, S.K., Gaidul, K.V., Kozlov, V.A., Chepurnov, A.A. The effect of inactivated Ebola virus on immune and hemopoietic cell activity. Russian Journal of Immunology, 3(3-4):263-5, 1998.
  22. Khaldoyanidi, S.K., Schnabel, D., Föhr, N., Zöller, M. Functional activity of CD44 isoforms in haemopoiesis of the rat. British Journal of Haematology, 96, 31-45, 1997.
  23. Khaldoyanidi, S.K., Denzel, A., Zöller, M. Requirement for CD44 in proliferation and homing of hematopoietic precursor cells. Journal of Leukocyte Biology, vol.60, pp.579-592, 1996.
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