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CALIFORNIA SCIENTISTS James Binley Todd Braciak Yang D. Dai Joanna Davies Brigitte Dudouet Richard A. Houghten Tony Hugli Valeria Judkowski J. Patrick Kampf Sophia Khaldoyanidi Alan Kleinfeld Prasad Koka Vipin Kumar Eugene G. Levin David Loskutoff Adel Nefzi Ron Ogata Clemencia Pinilla Claudia Raja Gabaglia Roy Riblet Fahu Samad Sally Sarawar Eli Sercarz Ingrid Schraufstatter Darcy Wilson FLORIDA SCIENTISTS Christopher Armishaw Colette Dooley Marc Giulianotti Richard A. Houghten Jose Luis Medina-Franco Karina Martinez Mayorga

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Education

• 1995 - B.A. Biology. Faculty of Exact & Natural Sciences, University of Buenos Aires, Argentina. Grade Point Average: 8.7 (scale: 0 to 10).
• 1997 - M.S. Molecular Biology. Faculty of Exact & Natural Sciences, University of Buenos Aires. Grade Point Average: 10 (scale: 0 to 10).
• 2002 - Ph.D. Immunology. Program between University of California San Diego, Faculty of Exact & Natural Sciences, University of Buenos Aires and Torrey Pines Institute for Molecular Studies, San Diego, CA, USA. Grade Point Average: 10 (scale: 0 to 10).

Awards

• Granted by "Fundación de la Hemofilia". A large proportion of hemophilic patients transfused with clotting factor concentrates between 1978 and 1984 became infected with different viruses. The Institute of Hematological Investigations, "M. R. Castex" functions as the Reference Center in Argentine for hemophiliac people. The aim of my project was to characterize the response to therapy in these patients, 1995-1998.
• Granted by "Fundación de la Hemofilia". The M.S. Thesis work was supported by this grant. The Scripps Research Institute, La Jolla, CA, USA, 1996-1997.

Professional Training

• 1994 - Scientific Journalism, carried out by "Instituto de Investigaciones Bioquímicas y Moleculares, Fundación Campomar", Buenos Aires, Argentina.
• 1997 - Medical Molecular Biology Training, applied to the diagnosis and treatment of human diseases, carried out by the Instituto de Investigaciones Bioquímicas y Moleculares "Fundación Campomar", Buenos Aires, Argentina.
• 2001 - Drug Discovery and Development, carried out by University of California San Diego, USA.

Professional Record

• Research fellow, Academia Nacional de Medicina, Buenos Aires, Argentina. Follow up of viral infections in hemophiliac patients. Interdisciplinary work between physicians, biologists and patients, 1994-1996.
• Research fellow, The Scripps Research Institute, department of Immunology, La Jolla, California, USA. Laboratory of Pr. D. Mosier under the supervision of Dr. Gaston Picchio.
  M.S. Thesis title: "Impact in Apoptosis and Cytokine Profile induced by different HIV strains in CD4+ T lymphocytes in vitro and Lymphocyte Depletion in vivo", 1996-1997.
• Predoctoral fellow, The Torrey Pines Institute for Molecular Studies, San Diego, CA, USA. Laboratory of Dr. Darcy Wilson and Faculty of Exact & Natural Sciences, University of Buenos Aires.
  Doctoral Thesis title: "Identification of peptide ligands specific for a diabetogenic CD4+ T cell population and evaluation of their use to treat Type 1 diabetes." 1998-2002.
• Postdoctoral Research Associate, The Scripps Research Institute, department of Immunology, La Jolla, California, USA. Laboratory of Pr. Nora Sarvetnick, 2002-2004.
• Research Scientist. Centre d'Immunologie de Marseille-Luminy (CIML), France, 2005 to 2008.
• Assistant Member. Torrey Pines Institute for Molecular Studies, San Diego, CA, USA, 2008 to date.

Bibliography

1. Wilson DB, Pinilla C, Wilson DH, Schroder K, Boggiano C, Judkowski V, Kaye J, Hemmer B, Martin R, Houghten RA. Immunogenicity. I. Use of peptide libraries to identify epitopes that activate clonotypic CD4+ T cells and induce T cell responses to native peptide ligands. J Immunol. 1999 Dec 15;163(12):6424-34.
2. Judkowski V, Pinilla C, Schroder K, Tucker L, Sarvetnick N, Wilson DB. Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice. J Immunol. 2001 Jan 15;166(2):908-17.
3. Borras E, Martin R, Judkowski V, Shukaliak J, Zhao Y, Rubio-Godoy V, Valmori D, Wilson D, Simon R, Houghten R, Pinilla C. Findings on T cell specificity revealed by synthetic combinatorial libraries. J Immunol Methods. 2002 Sep 1;267(1):79-97.
4. You S, Chen C, Lee WH, Wu CH, Judkowski V, Pinilla C, Wilson DB, Liu CP. Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides. J Immunol. 2003 Apr 15;170(8):4011-20.
5. Masteller EL, Warner MR, Ferlin W, Judkowski V, Wilson D, Glaichenhaus N, Bluestone JA. Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes. J Immunol. 2003 Nov 15;171(10):5587-95.
6. Judkowski V, Krakowski M, Rodriguez E, Mocnick L, Santamaria P, Sarvetnick N. Increased islet antigen presentation leads to type-1 diabetes in mice with autoimmune susceptibility. Eur J Immunol. 2004 Apr;34(4):1031-40.
7. Yadav D, Judkowski V, Flodstrom-Tullberg M, Sterling L, Redmond WL, Sherman L, Sarvetnick N. B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets. J Immunol. 2004 Sep 15;173(6):3631-9.
8. Judkowski V, Allicotti GM, Sarvetnick N, Pinilla C. Peptides from common viral and bacterial pathogens can efficiently activate diabetogenic T-cells. Diabetes. 2004 Sep;53(9):2301-9.
9. Judkowski V, Rodriguez E, Pinilla C, Masteller E, Bluestone JA, Sarvetnick N, Wilson DB. Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes. Clin Immunol. 2004 Oct;113(1):29-37.
10. Judkowski V, Pinilla C, Alicotti G, Flodstrom M, Sanna P, Sarvetnick N. Strong attraction may be dangerous: parameters for the development of long term commitment. Mol Immunol. 2004 Feb;40(14-15):1109-12.